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Article Abstract
A 69-year-old man with systemic sclerosis and interstitial pneumonia presented with an abnormal shadow in the right upper lung lobe. A thoracoscopic needle biopsy was performed on the right upper lobe lesion, and Mycobacterium malmoense was identified by 16S rRNA and rpoB gene sequencing. Surgical treatment was performed to obtain a radical cure, and lung squamous cell carcinoma and M. malmoense infection were detected in the resected specimen. We herein report the first case of the successful treatment of a patient with pulmonary M. malmoense infection and concomitant lung squamous cell carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331295 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.4633-24 | DOI Listing |
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Article Synopsis
- The study focuses on the clinical significance of Mycobacterium malmoense infections, especially in pulmonary specimens, noting that this pathogen is more relevant than other non-tuberculous mycobacteria.
- Through a systematic review and meta-analysis of existing literature, the researchers analyzed data from 188 individual patients and pooled data from 671 patients, finding that pulmonary infections were the most common, but a significant number also had extra-pulmonary or disseminated disease.
- The results suggest that a high percentage (68%) of patients had clinically relevant disease, and treatment regimens that include macrolides and rifamycins significantly improved survival rates in these patients.