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The drying process in agriculture is energy-intensive and traditionally relies on fossil fuels, which are becoming less reliable and more expensive. This study designed and simulated a hybrid solar hot plate dryer system using the computer to reduce reliance on fossil fuels. The system's main components are a flat plate collector, photovoltaic panels, and a wind turbine. This system was simulated in three cities of Iran, including Bushehr, Kerman, and Shahrekord, from May 22 to October 23. Results showed that Bushehr had the best wind turbine performance, producing 1.35 × 10 W annually. Shahrekord was ideal for solar energy, reaching solar radiation levels of about 4540 kJ/mhr in September and generating 6660 W of solar-heated water. Finally, by comparing the yearly yield, it was concluded that Bushehr had a higher yield than the other two cities due to its geographical location, which was 0.301. The results of this research indicated that Iran, with its sunny days and wind energy potential, will be a very suitable place for installing and operating the hot plate solar dryer system. Future studies should look at longer-term simulations, use real-time data, and consider cost-benefit analyses to improve system efficiency and applicability.
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http://dx.doi.org/10.1038/s41598-024-84236-z | DOI Listing |
Neuropharmacology
September 2025
Metabolic Disorders and Neuroscience Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Hyderabad Campus, Hyderabad, India. Electronic address:
Neuroinflammation is vital in vincristine-induced peripheral neuropathy (VIPN). Locally infiltrated macrophages polarize to pro-inflammatory M1-type, release inflammatory cytokines, and contribute to neuropathic pain. Histone deacetylase 3 (HDAC3) regulates macrophage polarization.
View Article and Find Full Text PDFBehav Pharmacol
October 2025
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR.
Chronic unpredictable mild stress (CUMS) is an approved method for the induction of depression in rodents. Lithium, as one of the oldest psychiatric drugs, can induce beneficial effects on mood state under stressful conditions. On the other hand, crocin (active component of Saffron) has antioxidant, procognitive, and mood-enhancer effects.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
July 2025
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
This study adopted a three-dimensional "effect-dose-mechanism" evaluation system to screen the optimal regimen of Yuxuebi Tablets(YXB) combined with ibuprofen(IBU) for chronic musculoskeletal pain(CMP) intervention and elucidate its pharmacological mechanism, so as to provide a scientific basis for the clinical application of the regimen. The experiments were conducted using 8-week-old ICR mice, which were randomly divided into sham operation(sham) group, model(CFA) group, IBU group, YXB group, stasis paralysis tablets combined with ibuprofen low-dose group(IBU-L-YXB), stasis paralysis combined with ibuprofen high-dose group(IBU-H-YXB), stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen discontinuation on the 10th day of administration(IBU-10-YXB), and stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen halving on the 10th day of administration(IBU-1/2-YXB) group. An animal model was established using the CFA plantar injection method.
View Article and Find Full Text PDFOxid Med Cell Longev
September 2025
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke Cancer Institute, Duke University School of Medicine, Durham 27710, North Carolina, USA.
Numerous cellular and animal studies demonstrated the ability of redox-active Mn(III) -alkyl- and -alkoxyalkylpyridyporphyrins (MnPs) to protect normal tissue while suppressing tumor growth. The mechanism primarily involves the modulation of NF-кB and Nrf2 signaling pathways via catalysis of MnP/HO-driven protein thiol oxidation. Such differential protection/suppression effects have paved the way of Mn porphyrins (commonly known as mimics of superoxide dismutase) into clinical trials, therefore introducing new line of therapeutics that are affecting cellular redox status/oxidative stress, rather than specific proteins.
View Article and Find Full Text PDFJ Med Microbiol
September 2025
Microbiology, Mater Pathology, Mater Hospital Brisbane, South Brisbane, QLD 4101, Australia.
Blood cultures are an important test for the diagnosis of sepsis, and the time to an accurate result can allow for optimized antibiotic therapy. The 'choc drop' is a commonly performed, reliable and cheap rapid identification method, using a drop of positive blood culture broth incubated for a short period (2-4 h) before performing matrix-assisted laser desorption/ionization time-of-flight MS on any early growth/microbiological veil present. Due to the short incubation time (~2 h), agar plates may not reach the target temperature for optimal bacterial growth, leading to reduced accuracy of identification.
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