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http://dx.doi.org/10.1093/humrep/deae287 | DOI Listing |
Dig Dis Sci
August 2025
Division of Gastroenterology and Hepatology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Background And Study Aim: Over three million hospital admissions are made annually in the United States for gastrointestinal diseases, one-third of which result in inpatient endoscopic procedures. Delays in procedures have medical and financial implications, including prolonging hospital stays, decreasing quality measures, and reducing patient satisfaction. We aim to identify factors affecting inpatient procedures' timely performance.
View Article and Find Full Text PDFPsychiatry Res
August 2025
Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Integrated Schizophrenia Recovery Program, Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada. Electronic address:
Background: Clozapine is the gold standard for treatment-resistant schizophrenia (TRS), yet only 40 % of patients respond. Clinicians often add other psychotropics despite limited evidence and possible harms. Canadian data on this practice remains sparse.
View Article and Find Full Text PDFObesity (Silver Spring)
August 2025
Medical University of South Carolina, Charleston, South Carolina, USA.
Objective: The hormone peptide YY (PYY; cleaved into Y-selective form PYY) is an attractive candidate for use as a complementary pharmacotherapy for obesity along with glucagon-like peptide-1 (GLP-1) receptor agonists. This series of studies investigated a novel long-acting PYY analogue (PYY1875) alone and as an add-on to semaglutide for treatment of obesity.
Methods: Weight loss and food intake were first investigated in obese male rats, followed by phase 1 and 2 clinical studies investigating efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of PYY1875 as monotherapy and in combination with semaglutide in participants with overweight or obesity.
Aesthetic Plast Surg
June 2025
Division of Plastic Surgery, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, USA.
The integration of artificial intelligence (AI) into surgical practice demands critical reflection-not only on its capabilities, but also on its appropriate role. We appreciate De Bernardis et al. for raising essential concerns about the limits of AI in operative planning, particularly in contexts where human judgment, healing trajectories, and esthetic discernment defy algorithmic modeling.
View Article and Find Full Text PDFNutrients
May 2025
2nd Department of Internal Medicine, Research Unit and Diabetes Center, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) is a growing global concern. Nutraceuticals offer an appealing approach by targeting key mechanisms, such as oxidative stress, inflammation, lipid metabolism, and insulin resistance. This narrative review examines the role of various nutraceuticals in MASLD treatment, including silymarin, vitamin E, omega-3, curcumin, berberine, and coenzyme Q10.
View Article and Find Full Text PDF