Polypharmacy in clozapine-treated patients: A retrospective analysis of 667 patients in Ottawa, Canada.

Background: Clozapine is the gold standard for treatment-resistant schizophrenia (TRS), yet only 40 % of patients respond. Clinicians often add other psychotropics despite limited evidence and possible harms. Canadian data on this practice remains sparse.

Mitochondrial and cardiovascular responses to aerobic exercise training in supine and upright positions in healthy young adults: a randomized parallel arm trial.

Objectives: Aerobic exercise training can increase skeletal muscle mitochondrial content. Supine exercise training with legs above the heart potentially augments these increases. However, the impact of supine exercise training on mitochondrial biogenesis and cardiovascular adaptations remains unclear.

Plantar flexor strength and size decrease following single-leg disuse in uninjured adults: A meta-analysis.

Introduction: Plantar flexors play a pivotal role in human locomotion and balance. Several original research studies and systematic reviews have characterised the impact of single-leg disuse on plantar flexor strength and size. However, no meta-analysis has quantified the effects of single-leg disuse on changes in plantar flexor strength and size in uninjured adults.

Do Surrogate Markers of Cardiorespiratory Fitness Predict Individual Changes in VO? A Randomized Controlled Trial.

The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO. Surrogate markers of CRF were time to fatigue on treadmill test (TTF), time trial performance (3kTT), resting heart rate (RHR), submaximal heart rate (SubmaxHR), and submaximal ratings of perceived exertion (SubmaxRPE). Twenty-five participants were randomized into a high-intensity interval training (HIIT: = 14) group or non-exercise control group (CTL: = 11).

Standard Deviation of Individual Response for VO Following Exercise Interventions: A Systematic Review and Meta-analysis.

Background: Although numerous attempts to demonstrate inter-individual differences in trainability across various outcomes have been unsuccessful, the investigation of maximal oxygen consumption (VO) trainability warrants further study.

Objective: Our objective was to conduct the first systematic review and meta-analysis to evaluate inter-individual differences in VO trainability across aerobic exercise training protocols utilizing non-exercising comparator groups.

Methods: We conducted a literature search across three databases: EMBASE, PubMed and SCOPUS.

Evaluating Reduced Blood Monitoring Frequency and the Detection of Hematological Abnormalities in Clozapine-Treated Patients With Schizophrenia: A Chart Review Study From the COVID-19 Pandemic.

Background And Hypothesis: In response to Health Canada's March 2020 directive, patients on clozapine for over 12 months were allowed to extend hematological testing intervals from 4 to 8 weeks during the COVID-19 pandemic. We hypothesized that this change would not affect the timely detection of hematological abnormalities in patients with severe mental illness.

Study Design: A chart review was conducted of patients at the Royal Ottawa who were prescribed clozapine from March 2019 to March 2021.

Risk of bias in exercise science: A systematic review of 340 studies.

Risk of bias can contribute to irreproducible science and mislead decision making. Analyses of smaller subsections of the exercise science literature suggest many exercise science studies have unclear or high risk of bias. The current review (osf.

Including supramaximal verification reduced uncertainty in VO response rate.

Many reports describe using a supramaximal verification phase-exercising at a power output higher than the highest power output recorded during an incremental cardiopulmonary test-to validate VO. The impact of verification phases on estimating the proportion of individuals who increased VO in response to high-intensity interval training (HIIT) remains an underexplored area in the individual response literature. This analysis investigated the influence of same-day and separate-day verification phases during repeated measurements (incremental tests-INCR1 and INCR2; incremental tests + supramaximal verification phases-INCR1+ and INCR2+) of VO on typical error (TE) and the proportion of individuals classified as responders (i.

The effects of single-leg disuse on skeletal muscle strength and size in the nonimmobilized leg of uninjured adults: a meta-analysis.

The effects of single-leg immobilization on changes in skeletal muscle strength and size in the nonimmobilized leg remain controversial. Some studies have shown decreases, or even increases, in skeletal muscle strength and size of the nonimmobilized leg, thus challenging its role as an internal control. Here, we meta-analyze changes in knee extensor strength and size in the nonimmobilized leg of noninjured adults who participated in single-leg disuse studies.

Single-leg disuse decreases skeletal muscle strength, size, and power in uninjured adults: A systematic review and meta-analysis.

We aimed to quantify declines from baseline in lower limb skeletal muscle size and strength of uninjured adults following single-leg disuse. We searched EMBASE, Medline, CINAHL, and CCRCT up to 30 January 2022. Studies were included in the systematic review if they (1) recruited uninjured participants; (2) were an original experimental study; (3) employed a single-leg disuse model; and (4) reported muscle strength, size, or power data following a period of single-leg disuse for at least one group without a countermeasure.

A Systematic Review Examining the Approaches Used to Estimate Interindividual Differences in Trainability and Classify Individual Responses to Exercise Training.

Many reports describe statistical approaches for estimating interindividual differences in trainability and classifying individuals as "responders" or "non-responders." The extent to which studies in the exercise training literature have adopted these statistical approaches remains unclear. This systematic review primarily sought to determine the extent to which studies in the exercise training literature have adopted sound statistical approaches for examining individual responses to exercise training.

Examining interindividual differences in select muscle and whole-body adaptations to continuous endurance training.

New Findings: What is the central question of the study? Do interindividual differences in trainability exist for morphological and molecular skeletal muscle responses to aerobic exercise training? What is the main finding and its importance? Interindividual differences in trainability were present for some, but not all, morphological and molecular outcomes included in our study. Our findings suggest that it is inappropriate, and perhaps erroneous, to assume that variability in observed responses reflects interindividual differences in trainability in skeletal muscle responses to aerobic exercise training.

Abstract: Studies have interpreted a wide range of morphological and molecular changes in human skeletal muscle as evidence of interindividual differences in trainability.

Molecular regulation of skeletal muscle mitochondrial biogenesis following blood flow-restricted aerobic exercise: a call to action.

Blood flow-restricted (BFR) exercise can induce training adaptations comparable to those observed following training in free flow conditions. However, little is known about the acute responses within skeletal muscle following BFR aerobic exercise (AE). Moreover, although preliminary evidence suggests chronic BFR AE may augment certain training adaptations in skeletal muscle mitochondria more than non-BFR AE, the underlying mechanisms are poorly understood.

Risk of bias and reporting practices in studies comparing VO responses to sprint interval vs. continuous training: A systematic review and meta-analysis.

Background: It remains unclear whether studies comparing maximal oxygen uptake (VO) response to sprint interval training (SIT) vs. moderate-intensity continuous training (MICT) are associated with a high risk of bias and poor reporting quality. The purpose of this study was to evaluate the risk of bias and quality of reporting in studies comparing changes in VO between SIT and MICT.

Exploring Differences in Cardiorespiratory Fitness Response Rates Across Varying Doses of Exercise Training: A Retrospective Analysis of Eight Randomized Controlled Trials.

Objective: This study tested the hypothesis that greater mean changes in cardiorespiratory fitness (CRF), in either the absence or presence of reduced interindividual variability, explain larger CRF response rates following higher doses of exercise training.

Methods: We retrospectively analyzed CRF data from eight randomized controlled trials (RCT; n = 1590 participants) that compared at least two doses of exercise training. CRF response rates were calculated as the proportion of participants with individual confidence intervals (CIs) placed around their observed response that lay above 0.

Increasing whole-body energetic stress does not augment fasting-induced changes in human skeletal muscle.

Fasting rapidly (≤ 6 h) activates mitochondrial biogenic pathways in rodent muscle, an effect that is absent in human muscle following prolonged (10-72 h) fasting. We tested the hypotheses that fasting-induced changes in human muscle occur shortly after food withdrawal and are modulated by whole-body energetic stress. Vastus lateralis biopsies were obtained from ten healthy males before, during (4 h), and after (8 h) two supervised fasts performed with (FAST+EX) or without (FAST) 2 h of arm ergometer exercise (~ 400 kcal of added energy expenditure).

A comparison of pain responses, hemodynamic reactivity and fibre type composition between Bergström and microbiopsy skeletal muscle biopsies.

This study tested the hypotheses that 1) skeletal muscle biopsies performed with the Bergström needle evoke larger perceptions of pain and greater hemodynamic reactivity compared to biopsies performed with the microbiopsy needle, and 2) both needles yield samples with similar fibre type compositions when samples are collected at similar skeletal muscle depths. Fourteen healthy (age: 21.6 ± 3.

Cardiorespiratory fitness and muscular endurance responses immediately and 2 months after a whole-body Tabata or vigorous-intensity continuous training intervention.

Young adults (52 females, 16 males; age = 21 ± 3 years; O: 41 ± 6 mL/(kg·min)) were randomized into 3 groups: () no-exercise control (CTL; = 15), () Tabata ( = 27), or () vigorous-intensity continuous training (VICT; = 26) groups for a 4-week supervised training period (4 sessions/week). O, time-to-fatigue (TTF), 5 km time-trial performance (TT), and muscular endurance were assessed at baseline, post-training (POST), and 2-month follow-up (FU). Response confidence intervals (CI) were used to classify individuals as likely responders (R; CI > 0).

A novel gravity-induced blood flow restriction model augments ACC phosphorylation and mRNA in human skeletal muscle following aerobic exercise: a randomized crossover study.

This study tested the hypothesis that a novel, gravity-induced blood flow restricted (BFR) aerobic exercise (AE) model will result in greater activation of the AMPK-PGC-1α pathway compared with work rate-matched non-BFR. Thirteen healthy males (age: 22.4 ± 3.

Investigating the reproducibility of maximal oxygen uptake responses to high-intensity interval training.

Objectives: To test the hypothesis that observed maximal oxygen uptake (VOmax) and time to fatigue (TTF) responses to two identical periods of standardized high-intensity interval training are reproducible.

Design: Fourteen recreationally active and healthy young males completed two identical four-week periods of high-intensity interval training (4×4-min intervals at 90-95% maximum heart rate [HR] separated by 3-min periods of active recovery at 70-75% HR). Training periods were separated by a three-month washout period.

Moving beyond threshold-based dichotomous classification to improve the accuracy in classifying non-responders.

We examined maximal oxygen consumption responses following exercise training to demonstrate the limitations associated with threshold-based dichotomous classification of responders and non-responders and proposed alternative methods for classification. Specifically, we: 1) calculated individual probabilities of response, and 2) classified individuals using response confidence intervals (CI) and reference points of zero and a smallest worthwhile change of 0.5 METs.

Does blood lactate predict the chronic adaptive response to training: A comparison of traditional and talk test prescription methods.

The purpose of this study was to test the hypotheses (i) that interindividual variability in acute blood lactate responses during exercise at 65% of peak work rate (WR; relative WR protocol (REL)) will predict variability in the chronic responses to exercise training and (ii) that exercising at an intensity that causes uncomfortable speech production (negative talk test (TT) stage (NEG)) elicits high acute blood lactate responses and large adaptations to training. Twenty-eight participants completed 4 weeks of exercise training consisting of REL (n = 14) or NEG (TT, n = 14). Fifteen additional participants were assigned to a no-exercise control group (n = 15).