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Article Abstract
Eleven undescribed piperidine alkaloids, arecachines A‒J (1-11), were isolated from the peels of Areca catechu. Compounds 8-11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra. Compounds 1-4, 6, and 8-11 were evaluated for the monoamine oxidases (MAOs) inhibitory activity. Among them, compounds 3, 4, 6, and 10 showed MAOA inhibitory activity with IC values of 7.85-55.96 μM, while compounds 1-4, 8, 10, and 11 showed MAOB inhibitory activity with IC values of 11.92-77.87 μM.
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| http://dx.doi.org/10.1016/j.phytochem.2024.114373 | DOI Listing |
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