Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Exercise intolerance is a hallmark symptom in adults with tetralogy of Fallot (TOF). This may be attributed to impairments in right ventricular (RV) function, augmentation in RV load, and their effect on left ventricular (LV) hemodynamics. To elucidate these mechanisms, we examined oxygen uptake (VO) and cardiac hemodynamics in TOF and healthy controls at rest and during exercise. At peak exercise, VO was lower in TOF. This was partially attributed to lower heart rate in conjunction with a blunted exercise-induced change in LV stroke volume from rest to compensate for the chronotropic incompetence. Additionally, at peak exercise, pulmonary-RV was higher in TOF. Additionally, at peak exercise, in TOF, pulmonary-RV coupling negatively correlated with VO , changes in LV end-diastolic volume, and changes in LV SV from rest. These findings reveal the reliance of LV hemodynamics on the interplay between RV systolic load and function during exercise in TOF.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.echo.2024.12.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impaired Pulmonary Vascular Reserve in Adults with Repaired Coarctation of Aorta: Prevalence, Correlates, and Association with Disease Severity.
J Am Soc Echocardiogr
September 2025
From the Department of Cardiovascular Medicine, Mayo Clinic Rochester, MN 55905.
Background: Pulmonary hypertension is associated with cardiovascular events, but when assessed at rest, it has limited sensitivity. Pulmonary vascular reserve can be assessed noninvasively using exercise echocardiography, but this has not been studied in adults with coarctation of aorta (COA). We hypothesized that adults with COA had worse pulmonary vascular reserve compared to controls, and that impaired pulmonary vascular reserve was associated with clinical indices of disease severity independent right ventricular (RV) indices at rest.
View Article and Find Full Text PDFExercise-induced arterial hypoxaemia in patients with heart failure with preserved ejection fraction.
J Physiol
September 2025
Institue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.
Some patients with heart failure with preserved ejection fraction (HFpEF) have demonstrated evidence of exercise-induced arterial hypoxaemia (EIAH). However, EIAH was not quantified using , , and measurements as previously conducted in healthy adults nor was EIAH quantified alongside simultaneous measurements of pulmonary vascular pressures, cardiorespiratory responses, or dyspnoea on exertion (DOE) in these patients. Given the effects of hypoxaemia on pulmonary vasoconstriction, cardiorespiratory responses, and DOE, we tested the hypothesis that patients with HFpEF and EIAH (EIAH) would demonstrate higher pulmonary vascular pressures, worse oxygen uptake, and greater DOE compared with patients without EIAH (EIAH).
View Article and Find Full Text PDFCritical Assessment of the Recommended Alert Limit Curves for Occupational Heat Exposure.
Am J Ind Med
September 2025
Department of Kinesiology, Indiana University School of Public Health, Bloomington, Indiana, USA.
Background: Occupational heat stress recommendations aim to achieve thermal equilibrium and keep core temperature (T) below 38.0°C. We assessed the recommended alert limit curves when: (1) work-rest ratios are adjusted based on wet-bulb globe temperature (WBGT) at a fixed rate of metabolic heat production (H) and (2) H is adjusted based on WBGT at a fixed work-rest ratio.
View Article and Find Full Text PDFPb-210 in volume samples: self-attenuation and scattering problems.
Appl Radiat Isot
September 2025
Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), 30 Reactorului Str., PO Box MG-6, Magurele, Ilfov County, RO-077125, Romania. Electronic address:
In this work we study the effect of the matrix of the source on the spectrum and on the full energy peak efficiency for low energy photons. Using realistic simulations carried out with PENELOPE 2018, including detector resolution, we show that small angle Compton scattering does contribute to the peak count rate, implying the dependence of the matrix effects on the linear attenuation coefficient μ and also on the scattering cross section. We show that the effect of Compton scattering can be removed from the apparent peak, resulting a "clean" peak depending only on μ.
View Article and Find Full Text PDFMetabolic cost of external work: a novel CPET parameter optimises characterisation of exercise performance in obese individuals.
Eur J Appl Physiol
September 2025
Department of Cardiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.
Purpose: Both obesity and cardiorespiratory fitness are crucial determinants of symptoms and prognosis. However, interpreting the gold-standard cardiopulmonary exercise test (CPET) is complicated by increasing body size and varying body composition. We hypothesised that the 'metabolic cost of external work' (or oxygen uptake (ml/min)/workload (Watts); V̇O/W), a body weight-independent determinant of endurance capacity, would reflect metabolic health more accurately than V̇O alone.
View Article and Find Full Text PDF