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Article Abstract
Aim: The aim of the present study was to define whether cardiac myosin contributes to energy conservation in the heart of hibernating mammals.
Methods: Thin cardiac strips were isolated from the left ventricles of active and hibernating grizzly bears; and subjected to loaded Mant-ATP chase assays, X-ray diffraction and proteomics.
Main Findings: Hibernating grizzly bears displayed an unusually high proportion of ATP-conserving super-relaxed cardiac myosin molecules that are likely due to altered levels of phosphorylation and rod region stability.
Conclusions: Cardiac myosin depresses the heart's energetic demand during hibernation by modulating its function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732570 | PMC |
| http://dx.doi.org/10.1016/j.molmet.2024.102084 | DOI Listing |
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