Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Prenatal exposure to cannabis (or more specifically, delta 9-tetrahydrocannabinol [Δ9-THC]) has been consistently linked to low birthweight. Animal models further show that Δ9-THC is associated with rapid postnatal growth. Whether this association is modified by breastfeeding is unknown.
Methods: In this exploratory study, we followed 128 mother-child pairs through 3 years. Urinary Δ9-THC and cannabidiol (CBD) were measured mid-gestation. Generalized linear models estimated the associations between Δ9-THC and neonatal body composition. A mixed-effects model estimated the association between Δ9-THC and body mass index (BMI) z-score trajectories. Interaction was assessed by a three-way product term (Δ9-THC × breastmilk months × age).
Results: Fifteen children (12%) had Δ9-THC exposure; three had concomitant CBD exposure. Prenatal exposure to Δ9-THC alone was associated with lower fat mass (-95 g, 95% confidence interval [CI]: -174, -14) and neonatal adiposity (-2.1%; 95% CI: -4.2, -0.4) followed by rapid postnatal growth (0.42 increase in BMI z-score per square root year; 95% CI: 0.12, 0.72). Breastfeeding modified this association (p = 0.04), such that growth was similar for those breastfed for 5 months whereas a shorter duration of breastfeeding was associated with 1.1 higher BMI z-score at 3 years (95% CI: 0.21, 2.05).
Conclusions: Our study suggests that prenatal exposure to Δ9-THC may alter early-life growth. Breastfeeding may stabilize rapid postnatal growth, but the impact of lactational exposure requires further investigation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669837 | PMC |
| http://dx.doi.org/10.1111/ijpo.13187 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Meta-analysis of the association between prenatal antibiotic exposure and risk of childhood attention-deficit/hyperactivity disorder.
J Affect Disord
September 2025
Department of emergency, West China Second University Hospital, Sichuan University, Chengdu, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, 610041, China; Department of Emergency, Chengdu Hi-Tech Zone Ho
Background: Studies examining the association between maternal antibiotic use during pregnancy and the risk of childhood attention-deficit/hyperactivity disorder (ADHD) have yielded inconsistent results. This meta-analysis synthesizes available evidence to establish a more comprehensive understanding of this association.
Methods: Observational studies published through October 2, 2024, were systematically searched from Cochrane Library, EMBASE, Web of Science, and PubMed databases.
Developmental Programming: Differing impact of prenatal testosterone and prenatal bisphenol-A -treatment on hepatic methylome in female sheep.
Mol Cell Endocrinol
September 2025
Department of Epidemiology, University of Michigan, Ann Arbor, USA. Electronic address:
Steroid hormones are integral to pregnancy and fetal development, regulating processes such as metabolism, inflammation, and immune responses. Excessive prenatal steroid exposure, through lifestyle choices or environmental chemicals, can lead to metabolic dysfunctions in offspring. The research focuses on how exposure to testosterone (T) and bisphenol A (BPA) affects the liver's DNA methylome, a key component of the epigenome influencing long-term health.
View Article and Find Full Text PDFPrenatal exposure to per- and polyfluoroalkyl substances: Association with child behavior in the environmental influences on child health outcomes (ECHO) Cohort.
Environ Int
August 2025
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC, USA; Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC, USA. Electr
Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely impact child neurodevelopment; however, epidemiologic findings remain inconclusive because of small sample sizes, limited exposure variability, and differing neurodevelopmental measures. We aimed to investigate the relationship between prenatal PFAS exposure and child behavior.
Methods: We pooled data from nine study sites in the nationwide Environmental influences on Child Health Outcomes (ECHO) Cohort.
Association of PM Exposure on Birthweight: Racial and Ethnic Disparities.
Paediatr Perinat Epidemiol
September 2025
Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, Texas, USA.
Background: The few studies that have examined the impact of PM on reduced birthweight across different percentiles of the conditional birthweight distribution have produced equivocal findings, and only two assessed whether these associations varied by race/ethnicity or by racial/ethnic composition of the neighbourhood where mothers lived.
Objective: We evaluated racial/ethnic differences in the association between prenatal PM exposure and birthweight across the birthweight distribution in a retrospective cohort study comprising 102,986 full-term singleton births in Harris County, Texas (2019-2020).
Methods: Census tract-level daily PM concentrations were estimated using 'XGBoost-IDW Synthesis', and averaged exposures over pregnancy.
Persistence of Cardiac Malprogramming in Late Gestational Fetal Sheep by Early to Mid-Gestational Testosterone Excess.
Am J Physiol Heart Circ Physiol
September 2025
Department of Pediatrics, Washington University, St. Louis, Missouri.
Excess testosterone (T) exposure from early to mid-gestation (days 30-90) leads to sexually dimorphic adverse cardiac left ventricular (LV) programming at fetal day 90 (term 147 days). Whether this sexually dimorphic impact is a direct effect of T or reprogramming that persists beyond early fetal life is unknown. We hypothesized that adverse sex-specific cardiac outcomes seen in early fetal life will persist in late gestational fetuses.
View Article and Find Full Text PDF