Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In recent years, glutamate has attracted significant attention for its roles in various brain processes. However, one of its key regulators, glutamate dehydrogenase (GDH), remains understudied despite its pivotal role in several biochemical pathways. Dysfunction or dysregulation of GDH has been implicated in aging and various neurological disorders, such as Alzheimer's disease and Parkinson's disease. In this review, the impact of GDH on aging, cognitive impairment, and neurodegenerative conditions, as exemplars of the phenomena that may affected by neuroplasticity, has been reviewed. Despite extensive research on synaptic plasticity, the precise influence of GDH on brain structure and function remains undiscovered. This review of existing literature on GDH and neuroplasticity reveals diverse and occasionally conflicting effects. Future research endeavors should aim to describe the precise mechanisms by which GDH influences neuroplasticity (eg. synaptic plasticity and neurogenesis), particularly in the context of human aging and disease progression. Studies on GDH activity have been limited by factors such as insufficient sample sizes and varying experimental conditions. Researchers should focus on investigating the molecular mechanisms by which GDH modulates neuroplasticity, utilizing various animal strains and species, ages, sexes, GDH isoforms, brain regions, and cell types. Understanding GDH's role in neuroplasticity may offer innovative therapeutic strategies for neurodegenerative and psychiatric diseases, potentially slowing the aging process and promoting brain regeneration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbr.2024.115399 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diagnostic Approaches for Clostridioides difficile Infection.
Infect Dis Clin North Am
September 2025
Division of Gastroenterology & Hepatology, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:
This article offers a clinically focused overview of Clostridioides difficile infection (CDI) diagnosis, emphasizing the need to test only symptomatic patients and to distinguish true infection from colonization. It reviews multistep diagnostic algorithms that pair glutamate dehydrogenase (GDH) testing or nucleic acid amplification tests (NAAT) with toxin assays to improve accuracy. The limitations of PCR-only approaches are discussed, with a strong emphasis on clinical correlation.
View Article and Find Full Text PDFObservation of Giardia duodenalis infection in Mongolian gerbils: Cysts isolated from bovine feces.
Parasitol Int
September 2025
College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China. Electronic address:
Assemblage E of Giardia duodenalis, primarily infecting ruminants, has been relatively understudied both in vivo and in vitro. Due to unsuccessful attempts at in vitro cultivation, this study focused on establishing an economical, stable, and clinically relevant experimental animal model for Assemblage E infections. Cysts were purified from bovine feces via 33 % zinc sulfate flotation, with Assemblage E identity confirmed by gdh gene sequencing.
View Article and Find Full Text PDFIn situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion.
J Biol Chem
September 2025
Department of Cell Physiology and Metabolism, University of Geneva Medical School, Geneva, Switzerland. Electronic address:
Upon glucose stimulation, metabolic pathways of pancreatic beta-cells promptly adapt metabolite levels inducing insulin secretion fine-tuned by mitochondrial glutamate dehydrogenase (GDH). Although well described in vitro, these responses cannot yet be captured in vivo due to the intrinsic nature of the islets scattered throughout the pancreas. Tested first in vitro, glutamate precursor glutamine enhanced glucose-stimulated insulin secretion without eliciting oxidative catabolism, as opposed to glucose.
View Article and Find Full Text PDFAn exploratory single-cell analysis of peripheral blood mononuclear cells from vedolizumab-treated Crohn's disease patients identifies response-associated differences among the plasmacytoid dendritic cells and classical monocytes.
Front Immunol
September 2025
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands.
Background: Vedolizumab (VDZ) is a monoclonal antibody approved for the treatment of Crohn's disease (CD). Despite its efficacy, non-response to VDZ is common in clinical practice with no clear understanding of how it manifests. Here, we performed an exploratory study characterizing the cellular repertoire of responders and non-responders to VDZ during treatment.
View Article and Find Full Text PDFSubstrate recycling amplification enabled by hierarchically mesoporous MOFs for the specific screening of pheochromocytoma and paraganglioma.
Biosens Bioelectron
December 2025
Key Lab for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:
The sensitive and specific diagnosis of pheochromocytoma and paraganglioma (PPGL) remains challenging due to the low abundance of their detectable biomarker of catecholamines (CAs) in serum. Herein, we established an enzyme-assisted substrate recycling amplification model based on a hierarchically mesoporous UiO-66-NH (HMAUiO) to address these difficulties. Such porous platform was constructed by the Hofmeister ion-assisted nanoemulsion method with mesoporous size beyond 20 nm, in which Pt (II) meso-tetra(4-carboxyphenyl)porphyrin (TCPP-Pt) was incorporated within the microporous framework to form an HMAUiO-Pt sensing probe.
View Article and Find Full Text PDF