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Antimicrobial resistance (AMR) poses a global public health concern. Recognizing the critical role of bacterial adhesion in pathogenesis of infection, anti-adhesive therapy emerges as a promising approach to impede initial bacterial attachment, thus preventing pathogenic colonization and infection. Natural anti-adhesive agents derived from food sources are generally safe and have the potential to inhibit the emergence of resistant bacteria. This comprehensive review explored diverse natural dietary components exhibiting anti-adhesive activities against several model enteric pathogens, including , , , and three key diarrheagenic (i.e., enterotoxigenic , enteropathogenic , and enterohemorrhagic ). Investigating various anti-adhesive products will advance our understanding of current research of the field and inspire further development of these agents as potential nutraceuticals or adjuvants to improve the efficacy of conventional antibiotics.
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http://dx.doi.org/10.1080/10408398.2024.2436139 | DOI Listing |
Adv Healthc Mater
September 2025
Laboratory of Advance Technologies of Materials, Ministry of Education, College of Medicine and School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
The absence of blood vessels and nerves in cartilage severely restricts its self-healing capacity. Meanwhile, the inherent anti-adhesive nature of articular cartilage matrix further complicates the integration of implanted scaffolds, leading to common issues such as scaffold displacement, reduced mechanical stability, impaired cell migration, and insufficient tissue regeneration. These challenges collectively render articular cartilage repair a formidable global issue.
View Article and Find Full Text PDFCurr Issues Mol Biol
July 2025
Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien 970374, Taiwan.
Urinary tract infections (UTIs) are among the most prevalent bacterial infections in women, with high recurrence rates and growing concerns over antimicrobial resistance. The need for alternative or adjunctive therapies has spurred interest in plant-based treatments, which offer antimicrobial, anti-inflammatory, antioxidant, and immune-modulatory benefits. This review summarizes the mechanisms of action, clinical efficacy, and therapeutic potential of various medicinal plants and natural compounds for preventing and treating UTIs in women.
View Article and Find Full Text PDFNutr Health
August 2025
Department of Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria.
poses a major threat to human health, primarily due to its tumorigenic potential and ability to cause tissue damage. Because of its strong association with gastric cancer and mucosa-associated lymphoid tissue lymphoma, is classified as a class I carcinogen. Its eradication has become a challenge due to increasing antibiotic resistance rates.
View Article and Find Full Text PDFInt J Mol Sci
July 2025
Department of Food and Drug, University of Parma, 43124 Parma, Italy.
poses health threats due to its resilience and potential to cause severe infections, especially in vulnerable populations. Plant extracts and/or phytocomplexes have demonstrated the capability of natural compounds in mitigating virulence. Here we explored the suitability of a computational pipeline envisioned to identify the molecular determinants for the recognition between the bacterial protein internalin A (InlA) and the human E-cadherin (Ecad), which is the first step leading to internalization.
View Article and Find Full Text PDFFuture Med Chem
July 2025
Department of Chemistry, Maynooth University, Maynooth, Co. Kildare, Ireland.
Aims: To explore novel anti-virulence strategies against Candida albicans by evaluating the structure-activity relationship (SAR) of aromatic glycoconjugates that inhibit fungal adhesion to buccal epithelial cells (BECs), focusing on the effect of the substituents on the aromatic ring.
Materials & Methods: A series of aromatic glycoconjugates containing divalent β-D-galactopyranosyl-1,2,3-triazol-4-ylmethylamide motif, important for anti-adhesion activity, were synthesized and assessed as inhibitors of C. albicans adhesion to BECs.