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Purpose: This study aimed to determine the reliability and concurrent validity of finger joint range of motion (ROM) measurement using augmented reality (AR)-based hand tracking in a sample of healthy hands. Additionally, the study aimed to determine which camera view of the hand provided ROM measurements with the highest concurrent validity at each joint.
Methods: A web application developed for smart devices using Google's MediaPipe Hands framework converted AR-generated hand landmark coordinates from camera feed into ROM angle measurements in real time for all joints. From each of five camera views, we recorded five sets of AR-based flexion and extension measurements at the metacarpophalangeal (MCP), proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints of normal index to small fingers. Test-retest reliability of the five AR-based measurements in each view was evaluated as was concurrent validity of AR-based measurements relative to manual goniometry, considered the reference standard. Given accepted inter-rater reliability of manual goniometry is 10°, we considered AR-based measurements within 10° of goniometry measurements to have "acceptable" concurrent validity.
Results: Forty-eight healthy hands (median age 31, 50% left, varying ethnicities) were measured. All joints demonstrated excellent test-retest reliability (intraclass correlation coefficient >0.75) in all views in flexion and ≥2 views in extension. AR-based flexion measurements were within 10˚ of goniometry in ulnar views of the index MCP, PIP, and DIP; the long MCP and PIP; and the ring PIP and DIP. In extension, multiple views at each joint consistently yielded AR-based measurements within 10° of goniometry.
Conclusions: AR-based measurement has high concurrent validity and reliability; however, optimal camera views vary joint to joint. Validation in pathologic hands is required.
Clinical Relevance: Given its excellent reliability, AR-based measurement has potential for use in monitoring changes in finger ROM after intervention, either by clinicians in-person or by patients performing remote measurements independently.
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http://dx.doi.org/10.1016/j.jhsa.2024.10.006 | DOI Listing |
Obes Surg
September 2025
Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Australia.
This rapid systematic review aimed to evaluate the diagnostic accuracy (concurrent validity, predictive ability, reliability) of indirect calorimetry (IC) for measuring resting energy expenditure (REE) in adults with overweight or obesity. PubMed and Web of Science searched for studies measuring REE by IC in adults with overweight or obesity and reported primary outcomes: concurrent validity, predictive ability, or reliability. N = 22 studies were included that evaluated n = 10 IC devices.
View Article and Find Full Text PDFNat Biotechnol
September 2025
Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.
RNA-protein interactions critically regulate gene expression and cellular processes, yet their comprehensive mapping remains challenging due to their structural diversity. We introduce PRIM-seq (protein-RNA interaction mapping by sequencing), a method for concurrent de novo identification of RNA-binding proteins and their associated RNAs. PRIM-seq generates unique chimeric DNA sequences by proximity ligation of RNAs with protein-linked DNA barcodes, which are subsequently decoded through sequencing.
View Article and Find Full Text PDFAm J Hum Genet
September 2025
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK. Electronic address:
Multiplex assays of variant effect (MAVEs) provide promising new sources of functional evidence, potentially empowering improved classification of germline genomic variants, particularly rare missense variants, which are commonly assigned as variants of uncertain significance (VUSs). However, paradoxically, quantification of clinically applicable evidence strengths for MAVEs requires construction of "truthsets" comprising missense variants already robustly classified as pathogenic and benign. In this study, we demonstrate how benign truthset size is the primary driver of applicable functional evidence toward pathogenicity (PS3).
View Article and Find Full Text PDFPLoS One
September 2025
Biobank of Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China.
Heart failure (HF) and lung cancer (LC) often coexist, yet their shared molecular mechanisms are unclear. We analyzed transcriptome data from the NCBI Gene Expression Omnibus (GEO) database (GSE141910, GSE57338) to identify 346 HF‑related differentially expressed genes (DEGs), then combined weighted gene co-expression network analysis (WGCNA) pinpointed 70 hub candidates. Further screening of these 70 hub candidates in TCGA lung cancer cohorts via LASSO, Random Forest, and multivariate Cox regression suggested CYP4B1 as the only independent prognostic marker.
View Article and Find Full Text PDFJ Alzheimers Dis
September 2025
The Framingham Heart Study, Framingham, MA, USA.
BackgroundWomen have a higher risk of dementia than men. Reproductive factors may be implicated.ObjectiveDetermine the association between reproductive factors (earlier menarche, later menopause, longer reproductive lifespan (RLS), post-menopausal hormone replacement therapy [pmHRT] use, and serum estradiol/estrone) and neurocognitive and neuroimaging markers of brain aging and incident dementia in cognitively healthy women.
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