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We propose and experimentally demonstrate a novel strategy to achieve dual-band symmetry-protected bound states in the continuum (BICs) in silicon metasurfaces. This strategy is based on the hybridization of Mie surface lattice resonances (SLRs) in periodic silicon bipartite nanodisk arrays, of which the central nanodisk displaced from the center of the unit cell. We show that dual-band electric quadrupole and magnetic dipole BICs can be supported in such a system, and transfer to quasi-BICs with ultrahigh measured quality factors up to 1240 at the Γ point. Taking advantage of the SLR characteristics, we show that the spectral separation and the quality factors of these two quasi-BICs can be conveniently tuned by varying the nanodisk diameter or the lattice period. Making use of these dual-band quasi-BICs, we numerically obtain bulk sensitivities above 480 nm/RIU and high figures of merit up to 1200. We also show that when the central nanodisk is not displaced but has different diameter, the silicon bipartite nanodisk array supports an electric dipole BIC that was referred to as subradiant SLR in the literature. Our work provides a new approach for realizing and tuning dual-band BICs, and the obtained ultrahigh- quasi-BICs can find potential applications in nonlinear optics, multimodal lasing, and optical sensing.
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http://dx.doi.org/10.1515/nanoph-2022-0427 | DOI Listing |
ACS Synth Biol
September 2025
A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russian Federation.
African swine fever virus (ASFV) is a large DNA virus that causes a highly lethal disease in pigs and currently has no effective vaccines or antiviral treatments available. We designed a protein switch that combines the DNase domain of colicin E9 (DNase E9) and its inhibitor Im9 with the viral protease cleavage site. The complex is only destroyed in the presence of an ASFV pS273R protease, which releases DNase activity.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
September 2025
Unsupervised visible-infrared person reidentification (UVI-ReID) has recently gained great attention due to its potential for enhancing human detection in diverse environments without labeling. Previous methods utilize intramodality clustering and cross-modality feature matching to achieve UVI-ReID. However, there exist two challenges: 1) noisy pseudo-labels might be generated in the clustering process and 2) the cross-modality feature alignment via matching the marginal distribution of visible and infrared modalities may misalign the different identities from the two modalities.
View Article and Find Full Text PDFJMIR Med Inform
September 2025
Department of Radiology, Air Force Medical Center, Air Force Medical University, Fucheng Road 30, Haidian District, Beijing, CN.
Background: Lateral malleolar avulsion fracture (LMAF) and subfibular ossicle (SFO) are distinct entities that both present as small bone fragments near the lateral malleolus on imaging, yet require different treatment strategies. Clinical and radiological differentiation is challenging, which can impede timely and precise management. On imaging, magnetic resonance imaging (MRI) is the diagnostic gold standard for differentiating LMAF from SFO, whereas radiological differentiation on computed tomography (CT) alone is challenging in routine practice.
View Article and Find Full Text PDFApoptosis
September 2025
State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400715, China.
Colorectal cancer (CRC) is one of the most common and lethal malignancies worldwide, with treatment failure often attributed to chemoresistance and evasion of apoptosis. Cathayanon E (CE), a natural chalcone derivative isolated from Morus alba, has shown anticancer potential, but its role and mechanism in CRC remain largely unexplored. In this study, CE significantly inhibited CRC cell proliferation and induced apoptosis both in vitro and in vivo.
View Article and Find Full Text PDFAnal Sci
September 2025
Department of Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, 739-8526, Japan.
Surface-enhanced Raman scattering (SERS) is a powerful analytical technique; however, its quantitative application has been limited by the instability of substrates and significant signal fluctuations. In this study, we demonstrated that 4-aminobenzenethiol (4-ATP) can be quantitatively detected through statistical analysis of SERS signal intensity distributions obtained using citrate-stabilized AuNPs, biotin-functionalized AuNPs, and gold nanoparticle (AuNP)-bound polystyrene (PS) microparticles. Raman spectra obtained in bulk aqueous solution under static conditions showed that the detection sensitivity of 4-ATP using AuNP-bound PS microparticles was approximately twice that achieved with citrate-stabilized AuNPs or biotin-modified AuNPs.
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