Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3967/bes2024.146 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anti-plasmid defense in hypervirulent involves Type I-like and Type IV restriction modification systems.
Emerg Microbes Infect
September 2025
Infectious Diseases Translational Research Programme, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Hypervirulent (hvKp) and classical multidrug-resistant (MDR) strains belong to distinct lineages and hvKp are typically characterized by hypermucoid capsules that have been shown to limit horizontal gene transfer (HGT), including plasmid acquisition. However, the convergence of hypervirulence and MDR is increasingly common worldwide. When we profiled 127 antibiotic-susceptible hvKp strains, we found that most (86%) are highly permissive to plasmid transfer despite their capsules.
View Article and Find Full Text PDFOvercoming Multi-Drug-Resistant Infections.
Microb Drug Resist
September 2025
Students Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Antimicrobial resistance (AMR) is one of the most important concerns in the world, occurring for both Gram-positive and Gram-negative bacteria. () is a Gram-negative bacterium belonging to the family of Enterobacteriaceae and also plays an important role in development of nosocomial infections. Three forms have emerged as a result of AMR including multi-drug resistant (MDR), extensively drug-resistant, and pan-drug-resistant.
View Article and Find Full Text PDFComputational investigation of mutations in PfCRT and PfDHFR proteins for Emerging Resistance of Plasmodium falciparum to Antimalarial drugs.
Mol Biochem Parasitol
September 2025
NyBerMan Bioinformatics Europe, Paddenstoelenlaan 8, 3451 PZ Utrecht, Netherlands.
The emergence of multidrug resistance in Plasmodium falciparum poses a serious threat to antimalarial treatment, particularly with growing resistance to artemisinin-based combination therapies (ACTs) and partner drugs like piperaquine. Mutations in key proteins, such as PfCRT (P. falciparum chloroquine resistance transporter) and PfDHFR (P.
View Article and Find Full Text PDFHost-directed immunotherapy to enhance treatment of Mycobacterium tuberculosis infection.
Int Immunopharmacol
September 2025
Weifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, School of Life Science and Technology, Shandong Second Medical University, PR China. Electronic address:
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains one of the leading causes of morbidity and mortality worldwide, particularly in low- and middle-income countries. The extensive use of antibiotics has led to the emergence of multidrug-resistant and extensively drug-resistant MTB strains, intensifying the challenges associated with TB treatment. In this context, host-directed immunotherapy has emerged as a promising adjunct strategy that aims to modulate the host immune response rather than directly targeting the pathogen.
View Article and Find Full Text PDFIntegrative Strategies Against Multidrug-Resistant Bacteria: Synthesizing Novel Antimicrobial Frontiers for Global Health.
Microb Pathog
September 2025
Central Research Laboratory and Molecular Diagnostics, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Postal code 442001, Wardha, Maharashtra, India.
Concerningly, multidrug-resistant bacteria have emerged as a prime worldwide trouble, obstructing the treatment of infectious diseases and causing doubts about the therapeutic accidentalness of presently existing drugs. Novel antimicrobial interventions deserve development as conventional antibiotics are incapable of keeping pace with bacteria evolution. Various promising approaches to combat MDR infections are discussed in this review.
View Article and Find Full Text PDF