Olfactory dysfunction in COVID-19; Self-report or olfactory dysfunction test?

Caspian J Intern Med

Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Published: October 2024


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Background: COVID-19 developed a sudden onset of smelling disorders. Researchers used self-reported or special tests to study this issue. We aimed to investigate whether quantitative-test smell disorders have a considerable difference from self-reported or not.

Methods: We searched 554 studies published between December 2019 to September 2020 by the PICO model. Our search strategies were based on MeSH terms in the electronic databases Web of Science (136 articles), Scopus (84 articles), and PubMed (334 articles). The duplicated articles were excluded, then the preferred reporting items for systematic reviews and meta-analysis guidance were utilized. Finally, we divided the studies into two (self-report (33 articles) and specific-test (9 articles)) groups.

Results: 33 (80%) articles expressed olfactory dysfunction by self-report of patients and 9(20%) studies were conducted by a specific test. Only three studies, one in self-report; ((internal reliability, Cronbach α = 0.84) and validity (r = -0.60, p < 0.001)) and two in specific-test groups; ((test-retest r=0.94) and another study (test-retest r >0.7)) conducted validity and reliability. Self-reported studies published a various range of prevalence (20% _97%) in patients with COVID-19. COVID-19 patients with a specific-test group were found to have a primary incidence of anosmia of over 65%, even reaching 98% depending on the types of tests.

Conclusion: Self-reporting of COVID-19 detection can be affected by sociodemographic factors. Although self-reported questionnaires are economical and easy to use, standardized tests provide more reliable comparisons and professional assessments. Therefore, standardized tests are recommended for more accurate screening over self-reporting.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607109PMC
http://dx.doi.org/10.22088/cjim.16.1.37DOI Listing

Publication Analysis

Top Keywords

olfactory dysfunction
12
studies published
8
studies self-report
8
standardized tests
8
articles
7
covid-19
5
studies
5
dysfunction covid-19
4
self-report
4
covid-19 self-report
4

Similar Publications

Background: Taste and smell disorders are more common in individuals with diabetes, particularly among those with low insulin sensitivity or central obesity. These disorders may affect glycaemic control by altering dietary habits. This study aimed to investigate self-reported taste and smell dysfunction in individuals with diabetes and explore associations with clinical and behavioural factors.

View Article and Find Full Text PDF

Background: Early identification of pathological α-synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease-modifying treatments.

Objectives: We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory dysfunction (iOD).

Methods: In this cross-sectional, case-control study, we included iOD participants and normosmic healthy controls (HC) aged 55 to 75 years without diagnoses of dementia with Lewy bodies, Parkinson's disease (PD), or other major neurological disorders.

View Article and Find Full Text PDF

Olfactory training (OT), a structured exposure to odors, is commonly used by otorhinolaryngologists to treat olfactory dysfunction. However, OT has been shown to improve cognition of people with cognitive or olfactory impairments and slow the age-related cognitive decline. This study investigated whether OT could enhance cognitive functions in older adults with an intact sense of smell, compared to younger adults.

View Article and Find Full Text PDF

Background: The World Health Organization recommends at-home management of mild COVID-19. While our preliminary evaluation provided evidence for saline nasal irrigation (SNI) and gargling in COVID-19, an update and risk-benefit assessment for self-care in Omicron infection is warranted, from treatment and preparedness perspectives, as new SARS-CoV-2 variants continuously emerge, while symptoms overlap with those of common colds and other upper respiratory tract infections.

Methods: Systematic literature searches for preclinical and clinical studies involving Omicron infection and saline, bias assessment, and review of outcomes (benefits, risks).

View Article and Find Full Text PDF

Olfactory training improves cognition and modifies brain networks in type 2 diabetes patients with mild cognitive impairment: A 16-week randomised controlled trial.

Diabetes Obes Metab

September 2025

Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Aims: Type 2 diabetes (T2D) related cognitive impairment links to comorbid and modifiable olfactory dysfunction; however, the efficacy of olfactory training (OT) to mitigate cognitive decline specifically in these patients with mild cognitive impairment (MCI) remains unestablished. This study aimed to determine whether OT alleviates cognitive decline in this population.

Materials And Methods: In this 16-week, open-label trial, 60 T2D participants with MCI were randomly assigned (1:1) to OT or routine care (control).

View Article and Find Full Text PDF