Analysis of influencing factors of exercise systolic blood pressure response in nonalcoholic fatty liver disease aged 40-60 years.

Objectives: This study investigated the influencing factors of exercise systolic blood pressure response (ESBPR) by cardiopulmonary exercise test (CPX) in nonalcoholic fatty liver disease (NAFLD) in people aged 40-60 years.

Methods: A total of 603 adults were enrolled in this study. The inclusion criteria of this cross-sectional study were adults who underwent health checks and CPX.

Results: There were significant differences in body mass Index (BMI) (26.80 ± 2.64 VS 23.31 ± 2.41, < 0.001) kg/m2, fasting blood glucose (FPG) (5.56 ± 0.94 VS 5.13 ± 0.55,  < 0.001) mmol/L, alanine aminotransferase (ALT), aspartate transaminase (AST), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) (1.13 ± 0.22 VS 1.43 ± 0.33,  < 0.001) mmol/L, low-density lipoprotein-cholesterol (LDL-C) (3.21 ± 0.79 VS 2.99 ± 0.68,  = 0.001) mmol/L, resting systolic blood pressure (SBP) (123.53 ± 14.73 VS 118.79 ± 14.79,  < 0.001) mmHg, resting diastolic blood pressure (DBP) (80.29 ± 9.62 VS 75.27 ± 10.41,  < 0.001) mmHg, peak SBP (184.01 ± 23.50 VS 172.81 ± 24.95,  < 0.001) mmHg, peak DBP (87.47 ± 10.50 VS 84.01 ± 11.46,  = 0.001) mmHg, oxygen pulse (VO2/HR) (0.88 ± 0.15 VS 0.92 ± 0.16,  = 0.004) ml/beat, exercise maximum heart rate, carbon dioxide Ventilation equivalent (VE/VCO2) (25.84 ± 4.43 VS 25.12 ± 3.58,  = 0.038), peak oxygen uptake (VO2 peak) (1.78 ± 0.45 VS 1.56 ± 0.46,  < 0.001) mL/min between the NAFLD and control groups. VE/VCO2 (OR = 0.822,  = 0.036) and oxygen uptake/work rate (VO2/WR) (OR = 0.517,  = 0.021) mL/min/watt were associated with a lower risk of ESBPR in NAFLD subjects. Resting SBP was associated with a higher risk of ESBPR in NAFLD patients (OR = 1.059,  = 0.003) and overweight NAFLD subjects (OR = 1.075,  = 0.002). ESBPR (OR = 1.268,  = 0.045), skeletal-muscle mass (OR = 1.305,  < 0.001), and SMI (OR = 1.315,  < 0.001) were linked to an elevated risk of NAFLD in individuals.

Conclusion: Our findings indicate that ESBPR is associated with an increased risk of NAFLD in individuals aged 40-60 years. Furthermore, in NAFLD subjects, VE/VCO2 and VO2/WR were found to be correlated with a decreased risk of ESBPR, whereas resting SBP was linked to an elevated risk of ESBPR. This will provide a research basis for the NAFLD subjects who have ESBPR at risk of adverse events during exercise.