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Recent advancements in deep learning techniques have significantly improved multi-label chest X-ray (CXR) image classification for clinical diagnosis. However, most previous studies neither effectively learn label correlations nor take full advantage of them to improve multi-label classification performance. In addition, different labels of CXR images are usually severely imbalanced, resulting in the model exhibiting a bias towards the majority class. To address these challenges, we introduce a framework that not only learns label correlations but also utilizes them to guide the learning of features and the process of oversampling. In this paper, our approach incorporates self-attention to capture high-order label correlations and considers label correlations from both global and local perspectives. Then, we propose a consistency constraint and a multi-label contrastive loss to enhance feature learning. To alleviate the imbalance issue, we further propose an oversampling approach that exploits the learned label correlation to identify crucial seed samples for oversampling. Our approach repeats 5-fold cross-validation process experiments three times and achieves the best performance on both the CheXpert and ChestX-Ray14 datasets. Learning accurate label correlation is significant for multi-label classification and taking full advantage of label correlations is beneficial for discriminative feature learning and oversampling. A comparative analysis with the state-of-the-art approaches highlights the effectiveness of our proposed methods.
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http://dx.doi.org/10.1007/s11517-024-03247-0 | DOI Listing |
J Imaging Inform Med
September 2025
Department of Biomedical Engineering, Gachon University, Seongnam-Si 13120, Gyeonggi-Do, Republic of Korea.
To develop and validate a deep-learning-based algorithm for automatic identification of anatomical landmarks and calculating femoral and tibial version angles (FTT angles) on lower-extremity CT scans. In this IRB-approved, retrospective study, lower-extremity CT scans from 270 adult patients (median age, 69 years; female to male ratio, 235:35) were analyzed. CT data were preprocessed using contrast-limited adaptive histogram equalization and RGB superposition to enhance tissue boundary distinction.
View Article and Find Full Text PDFNat Methods
September 2025
Electron Microscopy Science Technology Platform, The Francis Crick Institute, London, UK.
Volume correlative light and electron microscopy (vCLEM) is a powerful imaging technique that enables the visualization of fluorescently labeled proteins within their ultrastructural context. Currently, vCLEM alignment relies on time-consuming and subjective manual methods. This paper presents CLEM-Reg, an algorithm that automates the three-dimensional alignment of vCLEM datasets by leveraging probabilistic point cloud registration techniques.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin, 150040, PR China. Electronic address:
Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications. This study systematically investigated the oral absorption characteristics and tissue distribution of ME-2, a homogeneous polysaccharide from Auricularia auricula-judae, using a dual-labeling pharmacokinetic approach. First, a fluorescein-5-thiosemicarbazide (FTSC)-based quantitative method was established to analyze plasma pharmacokinetics and tissue concentrations of ME-2, demonstrating robust methodological stability (intra-/inter-day RSD < 15 %) and accuracy (recovery rate 95-103 %).
View Article and Find Full Text PDFFood Chem
September 2025
Wuxi Haihe Equipment Scientific & Technological Co., Wuxi, China.
To study the impact of pH-responsive labels prepared using traditional and different printing methods on fruit freshness monitoring and preservation, this study firstly optimized coaxial 3D printed labels by analyzing core-shell ratios and infill ratios, and predicted the impact of printing design on functionality of labels via four models. Then, the physicochemical properties of cast, dual-nozzle 3D printed, and coaxial 3D printed labels were compared. Finally, lightweight deep convolutional neural network models were used to enhance early warning intelligence.
View Article and Find Full Text PDFJ Proteome Res
September 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195, United States.
Retinol binding protein 4 (RBP4), the circulating carrier of retinol, complexes with transthyretin (TTR) and is a potential biomarker of cardiometabolic disease. However, RBP4 quantitation relies on immunoassays and Western blots without retinol and TTR measurement. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous absolute quantitation of circulating RBP4 and TTR is critical to establishing their biomarker potential.
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