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The broad acceptance of evidence-based psychosocial interventions as adjuncts to pharmacotherapy for bipolar disorder has been inhibited by the extensive training, supervision, and fidelity requirements of these approaches. Interventions that emphasize evidence-based strategies drawn from these modalities-rather than the full manualized protocols-may broaden the availability of psychotherapy for patients with bipolar disorder. In this article, psychosocial risk factors relevant to the course of bipolar disorder (stressful life events that disrupt social rhythms, lack of social support, family criticism and conflict, and lack of illness awareness or literacy) are reviewed, along with evidence-based psychosocial interventions (e.g., interpersonal and social rhythm therapy, cognitive-behavioral therapy, family-focused therapy, and group psychoeducation) to address these risk factors. The results of a component network meta-analysis of randomized psychotherapy trials in bipolar disorder are discussed. Manualized psychoeducation protocols-especially those that encourage active skill practice and mood monitoring in a family or group format-were found to be more effective, compared with individual psychoeducation or routine care, in reducing 1-year recurrence rates. Cognitive restructuring, regulation of daily and nightly routines, and communication skills training were core components associated with stabilization of depressive symptoms. The authors describe a novel psychoeducational approach-practical psychosocial management (PPM)-that integrates these core strategies into the personalized care of patients with bipolar disorder to reduce recurrences and enhance mood stability. PPM is designed to be implemented, without time-intensive training and oversight, by physician or nonphysician clinicians. Evaluating the efficacy and coverage of PPM will require implementation trials in community settings.
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http://dx.doi.org/10.1176/appi.psychotherapy.20240028 | DOI Listing |
Brain Behav
September 2025
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Inflammatory cytokine disturbance is a prominent outcome of immune dysregulation, extensively documented in bipolar disorder (BD). However, observational studies have exhibited inconsistent findings, and the causal relationships between inflammatory factors and BD remain unclear. Hence, this study aimed to uncover the causality between circulating inflammatory cytokines and BD.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2025
Departamento de Ciencias Químico-Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Mexico. Electronic address:
Chlorpromazine (CPZ) is a first-generation antipsychotic that has been widely used to treat an array of neurological conditions, including schizophrenia, bipolar disorder, and anxiety. Treatment of these chronic conditions with CPZ has been linked to elevated levels of reactive oxygen species (ROS), and accumulating evidence supports a link between ROS and chronic and degenerative pathologies, including cardiovascular diseases. Therefore, the aim of this study was to observe the presence of oxidative stress in porcine aortic endothelial cells (PAE) exposed to different concentrations of CPZ in vitro.
View Article and Find Full Text PDFJ Affect Disord
September 2025
Tianjin University, Medical School, Tianjin, China; Tianjin University, Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China; Tianjin University, State Key Laboratory of Advanced Medical Materials and Medical Devices, Tianjin, China.
Background: Abnormal gamma-band auditory steady-state response (gamma-ASSR) power has been reported in major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), but distinguishing between these disorders based solely on power remains challenging. Directed functional connectivity (DFC), which captures topological patterns of causal information flow, may provide more diagnostic-specific markers. However, conventional case-control framework often disregards the substantial individual heterogeneity, yielding unreliable biomarkers.
View Article and Find Full Text PDFJ Affect Disord
September 2025
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic addr
Background: In adolescents, the role of functional dysconnectivity in the default mode network (DMN), salience network (SAN), frontoparietal network (FPN), and reward network as markers of borderline personality disorder (BPD) remains uncertain.
Methods: A total of 45 adolescents with BPD comorbid with a mood disorder (bipolar disorder or major depressive disorder), 31 adolescents without BPD but with a mood disorder, and 47 healthy adolescents were enrolled in the study. All participants underwent resting-state functional connectivity magnetic resonance imaging.
J Child Psychol Psychiatry
September 2025
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Background: Subclinical hypomanic symptoms are fairly common in the general population but are linked to psychiatric and neurodevelopmental conditions. However, the genetic and environmental origins of these associations are unclear. This twin study examined the phenotypic and aetiological associations between subclinical hypomania and psychiatric and neurodevelopmental diagnoses.
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