Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-24-1029DOI Listing

Publication Analysis

Top Keywords

correction cd28
4
cd28 costimulatory
4
costimulatory domain-targeted
4
domain-targeted mutations
4
mutations enhance
4
enhance chimeric
4
chimeric antigen
4
antigen receptor
4
receptor t-cell
4
t-cell function
4

Similar Publications

The etiology of rheumatoid arthritis (RA) is still unclear, but it has been shown to be genetically related. While previous studies have shown a causal relationship between immune cells and RA, there has been no systematic evaluation of the causal relationship between immune cell characteristics and RA in terms of genetic variation. For this study, a comprehensive Mendelian randomization analysis was performed to determine the causal relationship between immune cell characteristics and RA.

View Article and Find Full Text PDF

[Exploring the Causal Relationship Between Circulating Immune Cells and Autoimmune Hepatitis Through Mendelian Randomization Analysis].

Sichuan Da Xue Xue Bao Yi Xue Ban

March 2025

( 610041) Department of Respiratory and Critical Care Medicine/Center for High Altitude Medicine/Institutes for Systems Genetics/National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To elucidate the causal relationship between specific immune cells and autoimmune hepatitis (AIH) using a two-sample Mendelian randomization (MR) approach.

Methods: A bidirectional MR analysis was conducted using data from large publicly accessible Genome-Wide Association Study (GWAS) databases. The inverse variance weighted (IVW) method was employed as the primary method to evaluate the relationship between 731 immune cell traits and AIH.

View Article and Find Full Text PDF

Mendelian randomization analysis reveals the causal relationship between immune cells and leukemia.

Discov Oncol

May 2025

Department of Hematology-Oncology, Fujian Children's Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000, Fujian, China.

Background: Increasing evidence indicates certain types of immune cells are linked to leukemia, but whether this link is causal has remained unclear.

Methods: A two-sample Mendelian randomization (MR) analysis was conducted to examine the causal relationship (CR) among 731 immune cell traits and leukemia. The inverse variance weighted (IVW) technique was applied, along with the weighted median and MR-Egger approaches, to analyze the data.

View Article and Find Full Text PDF

Background: Circulating immune cells reportedly affect diabetic neuropathy (DN). Although associations have been previously established between numerous biomarkers and diseases, elucidating their causal relationships remains challenging. Mendelian Randomization (MR) could overcome this difficulty by applying genetic instruments to discern causal links.

View Article and Find Full Text PDF

Background: Although phobia is a common psychiatric disorder, the underlying biological mechanisms have not been fully elucidated. Complex immune-brain interactions that affect neural development, survival, and function may have causal and therapeutic implications in psychiatric illnesses. In this study, the relationships between immune cell traits and phobia were analysed using Mendelian randomization to explore the biological mechanisms.

View Article and Find Full Text PDF