Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The kynurenine pathway (KP) is an important hub in neuroimmune crosstalk that is dysregulated in persons with multiple sclerosis (pwMS) and modulated by exercise in a modality-specific manner.
Objectives: To compare changes in the KP metabolite profile of pwMS (1) following combined treatments including either high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) during a 3-week multimodal rehabilitation, (2) to evaluate exercise response in relation to baseline systemic inflammation, and (3) to investigate associations of kynurenines with physical capacity and clinical outcomes.
Methods: For this secondary analysis of a randomized controlled trial, serum concentrations of kynurenines at baseline and after 3 weeks were determined using targeted metabolomics (LC-MS/MS). Exercise-induced changes in the KP metabolite profile according to treatment and baseline systemic inflammation (neutrophil-to-lymphocyte ratio (NLR) <3.12 versus ⩾3.12) were investigated using covariance analyses.
Results: Regardless of treatment, concentrations of tryptophan and most kynurenines decreased over time. Quinolinic acid concentration increased ( < .001). Participants with low and high NLR revealed differential exercise-induced changes in concentrations of kynurenines and NLR. The systemic inflammation markers neopterin ( = .015) and NLR ( < .001) decreased in the whole group and in participants with high NLR, respectively.
Conclusions: Combined treatments including HIIT or MICT do not differentially modulate the KP metabolite profile, with both reducing concentrations of most kynurenines. Baseline systemic inflammation may impact exercise-induced changes in the KP metabolite profile and anti-inflammatory effects of exercise in pwMS.
Trial Registration: clinicaltrials.gov (identifier: NCT04356248).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555752 | PMC |
| http://dx.doi.org/10.1177/11786469241284423 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Uncovering the Anti-Atherosclerotic Effect of Isoquercitrin via Microbiome Metabolic Modulation and Network Pharmacology.
J Agric Food Chem
September 2025
College of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030000, China.
Atherosclerosis (AS) is increasingly recognized as a disease influenced not only by lipid metabolism and inflammation but also by the gut microbiota and their bioactive metabolites. Isoquercitrin (ISO), a natural flavonoid with food-medicine homology, has shown promising antiatherosclerotic potential, yet its underlying mechanisms remain unclear. In this study, ISO administration significantly reduced plaque burden, improved lipid profiles, and restored gut microbial balance by enriching beneficial taxa, such as , , and .
View Article and Find Full Text PDFSex-Specific Vulnerabilities in the Kynurenine Pathway: Toward Precision Biomarkers for Adolescent Depression.
Biol Psychiatry
October 2025
Laureate Institute for Brain Research, Tulsa, Oklahoma; Department of Psychology, The University of Texas at Austin, Austin, Texas. Electronic address:
A novel biting rod model for assessing aggressive behavior in restraint-stressed rats: Role of 5-HT3 receptor and NF-κB-kynurenine pathways.
Physiol Behav
September 2025
Department of Pharmacology, School of Pharmacy & Technology Management, SVKM NMIMS Global University, Dhule 424001, Maharashtra, India. Electronic address:
Preclinical models are essential for understanding the pathophysiology of intermittent explosive disorder (IED) in rodents. However, current models fail to fully uncover the molecular mechanisms behind restraint stress-induced aggression. We introduced a restrainer combined with a biting rod to measure IED-associated symptoms in stressed rats.
View Article and Find Full Text PDFTryptophan metabolic dysregulation drives immune activation and cartilage degradation in osteoarthritis: Functional validation integrated with transcriptomic and single-cell RNA sequencing.
Biochem Biophys Res Commun
August 2025
Osteonecrosis and Joint Reconstruction Department, Xi'an Honghui Hospital, Xi'an, Shaanxi Province, China. Electronic address:
Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by complex immune and metabolic abnormalities. However, the role of amino acid metabolism in OA has remained insufficiently elucidated. In this study, we systematically explored the potential role of tryptophan metabolism abnormalities in the pathogenesis of OA.
View Article and Find Full Text PDFHeightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.
NPJ Metab Health Dis
September 2025
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ME/CFS patients often report a prodrome consistent with infection. We present a multi-omics analysis based on plasma metabolomic and proteomic profiling, and immune responses to microbial stimulation, before and after exercise.
View Article and Find Full Text PDF