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http://dx.doi.org/10.2214/AJR.24.32193 | DOI Listing |
Int J Radiat Oncol Biol Phys
August 2025
Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Department of Radiation Oncology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Acad
Purpose: This study evaluated the safety and efficacy of PEG hydrogels in reducing rectal radiation dose and complication during cervical cancer radical concurrent chemoradiotherapy.
Methods And Design: This phase 3, randomized, parallel-controlled trial (NCT05690906) conducted across nine centers in China (July 2022-January 2025). Participants were randomized 1:1 to receive a 10 mL PEG hydrogel injection (experimental group) or no injection (control group) after 50.
Drug Deliv Transl Res
August 2025
Centre de Recherche et d'Innovation Technologique en Environnement et en Sciences de la Santé (CRITESS), Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, B.P. 212, Democratic Republic of the Congo.
The prolonged use of conventional steroidal and non-steroidal anti-inflammatory drugs, as well as laxatives, often leads to severe adverse effects and toxicity, posing significant health risks. To address these challenges, we formulated a novel therapy based on (multi)metallic nanoparticles (MMNPs) green-synthesized from agricultural by-products, namely plantain peels (Musa paradisiaca) and Aloe vera gel. The MMNPs were characterized through UV-visible spectrophotometry, energy-dispersive X-ray spectroscopy (EDX), and dynamic light scattering (DLS), revealing nanoparticle sizes between 250 and 400 nm.
View Article and Find Full Text PDFJ Inflamm Res
August 2025
Post-Doctoral Research Center, Mayinglong Pharmaceutical Group Co., Ltd, Wuhan, 430070, People's Republic of China.
Background: Hemorrhoidal disease (HD) is characterized by the pathological dilation of anal vascular cushions, causing pain, itching and bleeding. Recent evidence links HD onset and progression to rectal inflammation. Medical Hemorrhoid Gel (MHG), a multi-component botanical preparation, has gained empirical validation for HD management.
View Article and Find Full Text PDFNeurogastroenterol Motil
August 2025
Division of Gastroenterology and Hepatology, Mayo Clinic in Florida, Jacksonville, Florida, USA.
Introduction: Investigation of an evacuation disorder is often pursued in patients with symptoms of obstructive defecation. High-resolution anorectal manometry (HR-ARM) is a simple, safe, and widely available test to diagnose pelvic floor dysfunction. A more costly and less accessible test is magnetic resonance defecography (MRD).
View Article and Find Full Text PDFBrachytherapy
August 2025
Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Purpose: To evaluate the safety and efficacy of gel spacer-assisted high-dose-rate (HDR) salvage brachytherapy for pelvic recurrence after definitive chemoradiotherapy (CRT) for cervical cancer.
Methods And Materials: We retrospectively analyzed 15 consecutive patients who underwent salvage HDR interstitial brachytherapy for pelvic recurrence following definitive CRT for cervical cancer between 2016 and 2024. Gel spacers were injected between the recurrent tumors and adjacent organs at risk (OARs), mainly the rectum and bladder, under transrectal ultrasound guidance at each brachytherapy session.