Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Ascites is common in advanced gastrointestinal cancers with peritoneal metastases (PM) and negatively impacts patient survival. No study to date has specifically evaluated the relationship between ascites, PM and survival outcomes in metastatic colorectal cancer (mCRC) and metastatic gastric cancer (mGC).
Objectives: This study aims to investigate and elucidate the relationship between malignant ascites, PM and survival outcomes in both mCRC and mGC patients.
Design: This is a retrospective analysis of prospectively collected clinical trial data of mCRC and mGC patients with PM.
Methods: We performed two pooled analyses, firstly of two Italian randomized trials enrolling patients with mCRC eligible for systemic therapy (TRIBE2; VALENTINO), and secondly of gastric cancer and peritoneal metastasis (GCPM) patients who underwent bi-directional therapeutic treatment comprising systemic and peritoneal-directed therapies.
Results: Of 900 mCRC patients, 39 (4.3%) had PM with malignant ascites. Compared to the group without PM, median progression-free and overall survival were significantly inferior in the ascites group (hazard ratio (HR) for progression-free survival (PFS) 1.68, 95% confidence interval (CI): 1.21-2.35, = 0.007; HR for overall survival (OS) 2.14, 95% CI: 1.57-3.01, < 0.001), but not in the group of PM without ascites (HR for PFS 1.10, 95% CI: 0.91 - 1.34; HR for OS 1.04, 95% CI: 0.84 - 1.30). Of 170 patients with GCPM, those with ascites had higher median Peritoneal Cancer Index scores (23 vs 9, < 0.001). Median OS was significantly inferior among those with ascites compared to those without (13.0 vs 21.0 months, HR 1.71, 95% CI: 1.16-2.52, = 0.007).
Conclusion: Ascites identifies a subgroup of patients with PM and poor outcomes, for whom tailored research are needed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536604 | PMC |
| http://dx.doi.org/10.1177/17588359241289517 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of the clinical features, laboratory findings, and outcomes of human fascioliasis in a global network: a retrospective mutlicenter study.
Ther Adv Infect Dis
September 2025
Department of Medicine, Division of Infectious Diseases, and Department of Microbiology and Immunology, Stony Brook University, 101 Nicolls Rd, HSC16-027 J, Stony Brook, NY 11794, USA.
Background: Fascioliasis, caused by and , is a neglected tropical disease that has significant medical and veterinary importance. This foodborne zoonotic trematodiases primarily affects poor rural populations in tropical and subtropical areas, where prevalence can be as high as 21%.
Objective: This study aims to characterize the clinical features, laboratory findings, and outcomes of fascioliasis in a real-world cohort.
Triazole-Pyrimidine Hybrids as EGFR Inhibitors via Synthesis, In Silico, In Vitro, and In Vivo Evaluation as Anticancer Agents.
Drug Dev Res
September 2025
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India.
The epidermal growth factor receptor (EGFR) is a common diver gene for lung cancer (NSCLC), which leads to an increasing death rate worldwide. This study reports the design, synthesis, and biological evaluation of triazole-clubbed pyrimidine derivatives (RDa-RDm) as potential anticancer agents. Thirteen compounds were synthesized and screened against the A549 lung cancer cell line.
View Article and Find Full Text PDFTriple Serosal Involvement in End-Stage Renal Disease (ESRD): A Case of Atypical Uremic Polyserositis With Elevated Serum-Ascites Albumin Gradient and Alkaline Phosphatase.
Cureus
August 2025
Department of Nephrology, Texas Tech University Health Sciences Center, Odessa, USA.
Uremic polyserositis is a rare and often underdiagnosed manifestation of end-stage renal disease (ESRD), typically characterized by concurrent or sequential inflammation of multiple serosal membranes. We report a diagnostically challenging case of a 40-year-old woman with ESRD on intermittent hemodialysis who presented with dyspnea following a missed dialysis session. Imaging revealed bilateral pleural effusions, a moderate-to-large pericardial effusion, and ascites.
View Article and Find Full Text PDFCancer of the ovary, fallopian tube, and peritoneum: 2025 update.
Int J Gynaecol Obstet
September 2025
Stanford Women's Cancer Center, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
In 2014, FIGO's Committee for Gynecologic Oncology revised the staging of ovarian cancer, incorporating ovarian, fallopian tube, and peritoneal cancer into the same system. Most of these malignancies are high-grade serous carcinomas (HGSCs). Stage IC is now divided into three categories: IC1 (surgical spill), IC2 (capsule ruptured before surgery or tumor on ovarian or fallopian tube surface), and IC3 (malignant cells in the ascites or peritoneal washings).
View Article and Find Full Text PDFAn intestinal histiocytic sarcoma in a collared peccary (Pecari tajacu): a case report.
Acta Vet Scand
September 2025
Department of Animal Sciences (DCA), Federal University of the Semi-Arid Region - UFERSA, Avenida Francisco Mota, 572, Costa e Silva, Mossoró, 59625-900, RN, Brazil.
Background: Research on cancer in wild animals provides important insights into the mechanisms of carcinogenesis. Histiocytic sarcomas comprise a rare malignant macrophage-dendritic cell lineage neoplasm in wildlife. This study reports a case of histiocytic sarcoma in the small intestine of a collared peccary (Pecari tajacu), describing its clinical, anatomopathological, and immunohistochemical aspects.
View Article and Find Full Text PDF