Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To determine the prevalence of genetic and endocrine abnormalities and to assess fetal, neonatal and surgical outcomes in cases of hypospadias associated with fetal growth restriction.
Method: A multicentric retrospective study was conducted across five prenatal diagnosis centers in Paris. The cohort encompassed all fetuses diagnosed with the combination of fetal growth restriction < 10th percentile (FGR) and hypospadias from 2013 to 2021. Maternal data, fetal outcome and results of prenatal investigations were collected, along with postnatal data, encompassing endocrinological and genetic assessments, functional aspects and surgical outcomes.
Results: Among the 82 patients included in the cohort, there were 14 (17%) terminations of pregnancy and four (5%) in utero deaths, leaving 64 (78%) live neonates, including five (6%) with early neonatal death. Among the 52 (63%) cases where hypospadias and FGR were considered as ultrasound-isolated anomalies, six (12%, [3.2%-20.8%]) exhibited chromosomic, genetic, or endocrinological abnormalities diagnosed half prenatally and half postnatally. Fifty percent of the overall hypospadias were proximal. Most children underwent surgical intervention before reaching 2 years of age, with 50% encountering complications and often required reintervention.
Conclusion: The association of FGR and hypospadias should not be underestimated as genetic or endocrinological abnormalities were identified even when hypospadias and FGR initially appear isolated. Additionally, the overall prognosis may be worsened using complex and iterative surgical procedures.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628206 | PMC |
| http://dx.doi.org/10.1002/pd.6699 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
FetalMLOps: operationalizing machine learning models for standard fetal ultrasound plane classification.
Med Biol Eng Comput
September 2025
Department of Computer Science, Università degli Studi di Bari Aldo Moro, Bari, Italy.
Fetal standard plane detection is essential in prenatal care, enabling accurate assessment of fetal development and early identification of potential anomalies. Despite significant advancements in machine learning (ML) in this domain, its integration into clinical workflows remains limited-primarily due to the lack of standardized, end-to-end operational frameworks. To address this gap, we introduce FetalMLOps, the first comprehensive MLOps framework specifically designed for fetal ultrasound imaging.
View Article and Find Full Text PDFDeterminants of fetal growth variability in ART conceptions.
J Assist Reprod Genet
September 2025
Obstetrics and Gynaecology Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
A Preliminary Study of the Relationship Between Zinc and the AhR Signaling Pathway During Palatal Development.
Cleft Palate Craniofac J
September 2025
School and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
ObjectiveTo investigate the effects of zinc concentration on palatal development in fetal mice and its association with the aryl hydrocarbon receptor (AhR) signaling pathway.MethodsPregnant C57BL/6J mice were fed diets with varying zinc concentrations and randomly divided into a zinc-rich (ZR) group, a normal-zinc (NZ) group, and a zinc-deficient (ZD) group. Embryonic development was observed, and the expression levels of AhR signaling pathway-related factors were examined.
View Article and Find Full Text PDFUterine Torsion due to Sigmoid Colon Volvulus in a Pregnant Woman: A Case Report.
Clin Case Rep
September 2025
Department of Obstetrics & Gynecology Motazedi Hospital, Kermanshah University of Medical Sciences Kermanshah Iran.
Sigmoid volvulus and uterine torsion are both rare and challenging conditions in pregnancy, and the coexistence of these conditions is particularly difficult to diagnose. Herein, we report a case of a 38-year-old pregnant woman at 30 weeks of gestation, with a history of two prior cesarean sections, who presented with severe abdominal pain, vomiting, and constipation, and was eventually diagnosed with both sigmoid volvulus and uterine torsion during surgery. Clinicians should consider the possibility of bowel obstruction when a pregnant woman presents with severe abdominal pain, vomiting, and constipation, as early diagnosis is crucial.
View Article and Find Full Text PDFEvaluating endometrial response to human chorionic gonadotropin: alterations in epigenetic regulation and extracellular vesicle cargo of endometrial stromal cells.
Hum Reprod Open
August 2025
Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Study Question: What is the effect of hCG on the epigenetic profile and the expression of other molecular factors in endometrial stromal cells (ESCs)?
Summary Answer: Our findings suggest that hCG treatment alters the molecular environment of decidualized ESCs, potentially influencing implantation and immune regulation through epigenetic modifications and changes in the levels of secreted proteins and micro-ribonucleic acids (miRNAs).
What Is Known Already: Embryo implantation depends not only on the quality of the embryo but also on the receptivity of the endometrium, the specialized lining of the uterus that undergoes dynamic changes to support pregnancy. Effective communication between the maternal and fetal compartments, facilitated by molecular signals and cellular interactions, is essential for successful implantation.