Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: This study aimed to assess the concordance of human epidermal growth factor receptor 2 (HER2) expression scoring by immunohistochemistry (IHC) among practicing pathologists in Japan, given the challenging nature of scoring and the critical role of HER2 status in breast cancer management.
Methods: Whole slide images (WSI) from 20 invasive breast cancer cases (1 representative WSI per case) selected to represent a diverse IHC scores and staining patterns were used in an online survey involving seven reference pathologists who established consensus HER2 IHC scores (0 to 3 +) decided by majority interpretation. Participating pathologists nationwide scored the same 20 WSI cases online using the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) 2018 guidelines. Deidentified case metadata were registered in the uPath system.
Results: A total of 144 participating pathologists responded. The scoring results of the participating pathologists most commonly agreed with the consensus IHC score, followed by a ± 1 point deviation and no survey responses with > 1 point deviation. The mean percentage of agreement with the consensus score for all 20 cases was 63.4%. In cases where the reference pathologists' scores were discordant, the participating pathologists also showed a lower concordance rate.
Conclusion: This study highlighted the current status of HER2 expression scoring by IHC for breast cancer among pathologists in Japan. These findings underscore the challenges in HER2 IHC scoring cases and emphasize the need for improved standardization and training, especially in the evolving landscape of HER2-targeted therapies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787237 | PMC |
| http://dx.doi.org/10.1007/s10549-024-07532-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Using a Refutation Text to Improve School-Based Speech-Language Pathologists' Knowledge of Dyslexia.
Lang Speech Hear Serv Sch
September 2025
Center for Childhood Deafness, Language and Learning, Boys Town National Research Hospital, Omaha, NE.
Purpose: Misconceptions about dyslexia abound among the public and educators alike. Refutation texts have been used to change misconceptions about a variety of topics, mostly in science education. The purpose of this study was to determine whether reading a refutation text about dyslexia could improve knowledge of dyslexia among school-based speech-language pathologists (SLPs).
View Article and Find Full Text PDFDiagnostic tips for multi-phase post-mortem computed tomography angiography interpretation in upper gastro-intestinal bleeding.
Int J Legal Med
September 2025
University Center of Legal Medicine Lausanne-Geneva, University of Geneva, Geneva University Hospitals, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland.
In the past 10 years, the Multi-phase Post-mortem Computed Tomography Angiography (MPMCTA) has considerably improved the quality and precision of postmortem diagnoses, particularly in cases with vascular implication. MPMCTA is known to have higher sensitivity for detecting the source of a hemorrhage than autopsy. Death by upper gastro-intestinal (GI) bleeding is not so uncommon in forensic practice.
View Article and Find Full Text PDFPragmatics: Exploring language use by younger generations in Pedi families.
S Afr J Commun Disord
August 2025
Department of Speech Pathology and Audiology, Faculty of Humanities, University of the Witwatersrand, Johannesburg, South Africa; and Department of Rehabilitative and Natural Sciences, Faculty of Health Sciences, University of Fort Hare, East London.
Background: The people of the Pedi culture place great value on, and take pride in, adhering to their culture, as reflected in the manner in which they communicate verbally and non-verbally. However, little is documented about the ways in which verbal and non-verbal language is used socially by the younger generations in the Pedi culture.
Objectives: This article examines how verbal and non-verbal social language skills and functions are used by the younger generations in Pedi families.
Need Analysis of Clinician-Oriented Integrated Precision Oncology Decision Support Tools: Qualitative Descriptive Study.
JMIR Hum Factors
September 2025
College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Background: The rapid advancement of next-generation sequencing has significantly expanded the landscape of precision medicine. However, health care professionals face increasing challenges in keeping pace with the growing body of oncological knowledge and integrating it effectively into clinical workflows. Precision oncology decision support (PODS) tools aim to assist clinicians in navigating this complexity, yet their current functionalities only partially address clinical needs.
View Article and Find Full Text PDFSafety of artificial intelligence-assisted optical diagnosis for leaving colorectal polyps in situ during colonoscopy (PRACTICE): a non-inferiority, randomised controlled trial.
Lancet Gastroenterol Hepatol
October 2025
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Background: Guidelines recommend leaving in situ rectosigmoid polyps diagnosed during colonoscopy that are 5 mm or smaller if the endoscopist optically predicts them to be non-neoplastic. However, no randomised controlled trial has been done to examine the efficacy and safety of this strategy.
Methods: This open-label, multicentre, non-inferiority, randomised controlled trial enrolled adults age 18 years or older undergoing colonoscopy for screening, surveillance, or clinical indications across four Italian centres.