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http://dx.doi.org/10.1073/pnas.2420068121 | DOI Listing |
Poult Sci
August 2025
Technology Center of Shijiazhuang Customs, Shijiazhuang 050051, China; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China. Electronic address:
Goose astrovirus (GAstV) is an important pathogen causing joint and visceral gout in goslings. Its high incidence and mortality had caused enormous economic losses to the goose farming industry. To achieve the simultaneous and rapid identification and detection of Goose astrovirus genotype 1 (GAstV-1) and genotype 2 (GAstV-2), the present study aimed to design and synthesize specific recombinase polymerase amplification (RPA) primers and exo probes targeting the ORF1b gene of GAstV.
View Article and Find Full Text PDFCent Nerv Syst Agents Med Chem
August 2025
Neuroscience Division, Department of Pharmacology, ISF College of Pharmacy (An Autonomous College), Moga-142001, Punjab, India.
Epilepsy is a common neurological condition marked by frequent seizures, which often accompanies cognitive and psychological difficulties. With an estimated 65 million sufferers worldwide, epilepsy imposes an enormous burden on individuals, families, and healthcare systems. Seizures are categorized into focal, generalized, and seizures with unknown onset.
View Article and Find Full Text PDFAppl Environ Microbiol
August 2025
Institute of Microbiology, State Key Laboratory for Vegetation Structure, Function and Construction (VegLab), College of Life Sciences, Zhejiang University, Hangzhou, China.
Iron is a vital cofactor for enzymes essential to many biological processes, yet in excess, it poses a danger to all living organisms. In order to ensure survival and proliferation under fluctuating environmental iron levels, bacteria evolve sophisticated regulatory systems to maintain iron homeostasis. Unlike master regulator Fur, a large portion of other players remains poorly defined.
View Article and Find Full Text PDFPLoS One
August 2025
Department of Pharmacy, Shaoxing People's Hospital, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, People's Republic of China.
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The global burden of NAFLD is increasing. This study used the Global Burden of Disease (GBD) 2021 study data to assess the burden and development trends of NAFLD from 1990 to 2021.
View Article and Find Full Text PDFCureus
July 2025
Medical Affairs, Cipla Ltd., Mumbai, IND.
Background: Heart failure is a burgeoning disease that imposes an enormous social and economic burden globally. It presents a significant public health challenge due to its high morbidity and mortality. In recent years, notable advancements have been made in the pharmacological treatment of heart failure with reduced ejection fraction (HFrEF), with guideline-directed medical therapy (GDMT) emerging as the cornerstone of HFrEF management.
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