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• For children with growth deficiency, once-weekly injections were less of a burden than once-daily injections. • The safety of weekly was similar to that of daily . • Compared with daily injections, children with growth deficiency may be less likely to miss weekly injections. ○ This is because weekly injections were less of a burden and were less likely to interfere with daily activities compared with daily injections. The purpose of this plain language summary is to help you to understand the findings from recent research. • is used to treat the condition under study that is discussed in this summary. Approval varies by country; please check with your local provider for more details. • The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence and not on the results of a single study. . Treatment burden of weekly versus daily in children with growth deficiency: a randomized study. 2022; 6(10): bvac117. DOI: 10.1210/jendso/bvac117.
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http://dx.doi.org/10.1177/20420188241274363 | DOI Listing |
Endocr Connect
September 2025
Department of Paediatric Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Background: Limited data are available on the growth response to growth hormone (GH) treatment of very young children with GH deficiency (GHD). In the present analysis, we compared clinical outcomes after GH treatment in children with GHD aged <2 and ≥2 years at the start of GH treatment.
Methods: We analysed pooled data from two observational studies of paediatric patients who received Norditropin® treatment: NordiNet® IOS (NCT00960128) and the ANSWER Program (NCT01009905).
Front Oncol
August 2025
Department of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Snai2 is a transcription factor that inhibits the proliferation of cervical cancer cells and tumor growth. The expression of Snai2 inhibited the expression of β-catenin and impaired Wnt/β-catenin signaling pathway activity. The results of the RNA sequence in Snai2-overexpressing cervical cancer cells implied a strong correlation between Snai2 and TRIM31 with ubiquitin ligase activity.
View Article and Find Full Text PDFInt J Gen Med
August 2025
Department of Pediatrics, Fujian Medical University Union Hospital, Fujian, 350000, People's Republic of China.
Purpose: To investigated the effect of pediatric massage combined with comprehensive management on height improvement in children with short stature.
Patients And Methods: This retrospective analysis included medical records of 80 children diagnosed with short stature, who received treatment at Wuhu Hospital of Traditional Chinese Medicine between April 2022 and April 2023. According to the recorded treatment modalities, patients were divided into two groups: the control group received standard comprehensive management (including psychological health guidance, diet, sleep, exercise), while the massage group received additional pediatric syndrome-based massage therapy alongside comprehensive treatment.
Mol Genet Metab Rep
December 2025
Pediatric Critical Care Medicine, Department of Pediatrics NewYork-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, United States of America.
encodes NADH: ubiquinone oxidoreductase core subunit V1, a key component of mitochondrial Complex 1. Biallelic pathogenic variants in this gene produce a broad and variable phenotypic spectrum in affected individuals, including ophthalmoplegia, developmental delays, brain imaging abnormalities, and recurrent episodes of emesis and lactic acidemia. We report female siblings compound heterozygous for two missense variants (Arg40Gln, Val245Met) in with unusual presentations of this condition.
View Article and Find Full Text PDFFront Pediatr
August 2025
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Bone age assessment is a critical tool for evaluating skeletal maturity in children and adolescents, with implications for growth monitoring and clinical decision-making. While traditional radiographic methods such as the Greulich-Pyle and Tanner-Whitehouse systems remain the gold standard, concerns over ionizing radiation exposure have spurred interest in ultrasound-based alternatives. This mini-review synthesizes current evidence on ultrasound bone age assessment, highlighting its advantages as a radiation-free, non-invasive modality with strong correlations to radiographic standards.
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