Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In schistosomiasis mansoni (SM), periportal fibrosis (PPF) arises due to an inflammatory response exacerbated by parasite eggs in the intrahepatic portal space, culminating in the deposition of collagen and extracellular matrix proteins. This fibrosis results from a remodeling process of the extracellular matrix, in which metalloproteinases play a significant role. The study evaluated the association between MMP-3 polymorphism (-1171 5A>6A) (rs 3025058) and sociodemographic factors with PPF in individuals with SM. This is an analytical cross-sectional study involving 242 individuals infected with S. mansoni, of these 122 were diagnosed with hepatosplenic form (HS) and 119 hepatointestinal form (HI), all from the state of Pernambuco, Brazil. Polymerase chain reaction with restriction enzyme digestion (Psyl) was used to determine the MMP-3 polymorphism (-1171 5A>6A). There was a significant association between the male gender and the HS form (OR = 1.7623 95% CI [1.0481-2.9631]; p-value = 0.0439) as well as individuals aged over 41, also had a greater chance of developing this clinical form of the disease (OR = 2.8299; 95% CI [1.5211-5.2650]; p-value = 0.0014), with greater emphasis on individuals over 61 years old (OR= 8.5541; 95% CI [3.6895-19.8326], p-value= 0.0000). There was no statistically significant association between the MMP-3 polymorphism (-1171 5A>6A) between the clinical groups (5A6A CI [0.7144-1.9879] p-value 0.5882 5A5A CI [0.0912-2.9231] p-value 0.7331 5A6A / 5A5A CI [0.6904-1.8937] p-value 0.6949). In conclusion, the results showed no association between the MMP-3 polymorphism (-1171 5A>6A) and the development of PPF. In addition, males, and age over 41 were predictive factors for the HS form of the disease in this Brazilian population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.actatropica.2024.107450 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Matrix Metalloproteinases 1 and 3 in Ovarian Cancer: Diagnostic and Prognostic Potential of Genetic Variants and Expression Profiling.
Diagnostics (Basel)
June 2025
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Ovarian carcinoma (OC) is one of the foremost factors in female carcinoma-related fatalities worldwide. Matrix metalloproteinases () are key mediators of tissue remodeling and are linked to tumor aggressiveness, yet there is still a lack of information on the link between genetic changes in and the onset and progression of OC in Egyptian women. This study examines the effects of immunoreactive biomolecule variations of , as well as the and genetic variants, on OC risk and progression in Egyptian women.
View Article and Find Full Text PDFAssociation between matrix metalloproteinase-3 gene polymorphism and susceptibility to chronic periodontitis: A systematic review and meta-analysis.
J Med Biochem
September 2024
Jinan Stomatological Hospital, Department of Periodontics and Oral Mucosa, Jinan, China.
Background: This study aimed to explore the correlation between the Matrix Metalloproteinase-3 (MMP-3) 1171 5A/6A gene polymorphism and susceptibility to Chronic Periodontitis (CP).
Methods: Following the PRISMA guidelines, a systematic search was conducted across four electronic databases (PubMed, Embase, Web of Science, and Cochrane Library) without any time or language limitations. The selection criteria included case-control studies examining the association between the MMP-3 gene polymorphism and CP.
The Association of Matrix Metalloproteinase-1, -2, -3, -7, and -13 Gene Polymorphisms With Peri-Implantitis in an Iranian Population: A Case-Control Study.
Clin Exp Dent Res
December 2024
Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objectives: Peri-implantitis (PI) is the most common biological issue surrounding dental implants. According to current knowledge, the aforementioned complication is not equally distributed across different populations, and gene polymorphisms might be one contributing factor. The current study aimed to examine the association between gene polymorphisms of matrix metalloproteinase- (MMP-) 1, -2, -3, -7, and -13 with PI in an Iranian demographic.
View Article and Find Full Text PDFInfluence of metalloproteinase-3 (-1171 5A>6A) polymorphism on periportal fibrosis in patients with schistosomiasis mansoni, Pernambuco, Brazil.
Acta Trop
December 2024
Gastroenterology Department, Hospital das Clínicas/EBSERH - Federal University of Pernambuco - UFPE, Recife, Brazil.
Article Synopsis
- Schistosomiasis mansoni (SM) leads to periportal fibrosis (PPF) due to inflammation from parasite eggs, resulting in collagen and matrix protein buildup in the liver.
- The study involved 242 individuals infected with S. mansoni in Pernambuco, Brazil, assessing the link between MMP-3 gene polymorphism (-1171 5A>6A) and PPF, alongside various sociodemographic factors.
- Findings revealed no significant link between MMP-3 polymorphism and PPF; however, male gender and age over 41 were identified as predictors for the hepatosplenic form of the disease.
Evaluation of matrix metalloproteinase-1, -2, -3, -7, and -13 gene polymorphisms in patients with chronic periodontitis and healthy controls.
Clin Oral Investig
December 2023
Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study examines the link between specific matrix metalloproteinase (MMP) gene polymorphisms and chronic periodontitis (CP) in an Iranian population by comparing 87 CP patients with 89 healthy individuals.
- Results show that variations in the MMP-1, MMP-3, and MMP-7 genes are significantly associated with CP risk, while MMP-2 and MMP-13 do not show a significant effect.
- Findings suggest that certain gene variants could influence the likelihood of developing CP, highlighting the importance of considering these factors in clinical periodontal treatment strategies.