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To assess the response to monocular occlusion test in basic type intermittent exotropia (IXT) and to evaluate the surgical outcomes of titrated surgery based on the test's result. Medical records were retrospectively reviewed for patients who underwent bilateral lateral rectus recession for basic type IXT. Patients were categorized into two groups: those who underwent a preoperative diagnostic monocular occlusion test (occlusion group) and those who did not (no occlusion group). In the occlusion group, patients exhibiting a change in deviation angle of ≥ 5 prism diopters (PD), either at distance or near fixation following occlusion therapy, were classified as responders, and augmented surgery was performed for patients with an increased deviation. A total of 215 patients were included in this study, with 79 patients (36.7%) in the no occlusion group and 136 patients (63.3%) in the occlusion group. In the occlusion group, while the mean distance deviation did not significantly change, the mean near deviation significantly increased from 27.2 ± 7.7 PD to 32.5 ± 8.6 PD after diagnostic monocular occlusion (p < 0.001). 58% (58%) of patients showed an increase in near deviation angle of 5 PD or more. Patients with good fusional control at near fixation were more likely to show a change in their deviation after the occlusion (odds ratio = 1.722, p = 0.028). The success rate of the strabismus surgery was significantly higher, and recurrence rate was significantly lower in the occlusion group compared to the no occlusion group (p = 0.025 and p = 0.030), while overcorrection rate was not significantly different between the two groups (p = 1.000). Over half of the patients with basic type IXT demonstrated a significant increase in near deviation angle after diagnostic monocular occlusion. Diagnostic monocular occlusion may be useful for revealing the maximum deviation angle at near fixation and may help determine the optimal surgical dosage in basic type IXT.
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http://dx.doi.org/10.1038/s41598-024-77213-z | DOI Listing |
J Integr Neurosci
August 2025
Department of Neurology, Peking University First Hospital Taiyuan Hospital, 030000 Taiyuan, Shanxi, China.
Background: Remote ischemic conditioning (RIC), a novel neuroprotective therapy, has broad potential for reducing the occurrence and recurrence of cerebrovascular events, yet its mechanisms are not incompletely understood. The aim of this study is to investigate whether RIC alleviates apoptosis, inflammation, and reperfusion injury in rat models of ischemic stroke by regulating the Elabela (ELA)-apelin-Apelin receptor (APJ) system.
Methods: We established a rat model of middle cerebral artery occlusion (MCAO) with ischemia-reperfusion injury, and RIC was administered twice daily for 3 days post-MCAO.
J Integr Neurosci
August 2025
Department of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, 150001 Harbin, Heilongjiang, China.
Background And Purpose: Ciprofol, a novel intravenous anesthetic, has been shown to exert protective effects against ischemic stroke, a leading cause of death and disability; however, its molecular mechanisms remain unclear. This study aimed to explore the molecular mechanisms underlying the neuroprotective effects of ciprofol using metabolomics.
Methods: This study used a middle cerebral artery occlusion (MCAO) rat model to simulate cerebral ischemia-reperfusion injury (CIRI).
J Neuroendovasc Ther
August 2025
Department of Neurological Surgery, Kishiwada Tokushukai Hospital, Kishiwada, Osaka, Japan.
Objective: The distal transradial approach has been one of the options for endovascular neurointervention because of the low risk of puncture site complications. However, the conventional and distal transradial artery approaches frequently cause cannulation-induced vasospasms, which can usually be prevented by vasodilators. The aim was to evaluate the effects of local infiltration using a puncture site cocktail of lidocaine mixed with nitroglycerin on puncture success and vasospasm for distal transradial cerebral angiography.
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August 2025
School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Background: Ischemic stroke (IS), the leading stroke subtype (∼87%), arises from vascular occlusions, triggering brain necrosis through ischemia-reperfusion injury. Ferroptosis, an iron-driven cell death via Fe-mediated lipid peroxidation, is implicated in IS pathology. This study demonstrates that enoyl-coA hydrolase 1 (ECH1) may serve as a peripheral biomarker and therapeutic target for IS based on ferroptosis signaling.
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August 2025
Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada.
Precision livestock farming increasingly relies on non-invasive, high-fidelity systems capable of monitoring cattle with minimal disruption to behavior or welfare. Conventional identification methods, such as ear tags and wearable sensors, often compromise animal comfort and produce inconsistent data under real-world farm conditions. This study introduces Dairy DigiD, a deep learning-based biometric classification framework that categorizes dairy cattle into four physiologically defineda groups-young, mature milking, pregnant, and dry cows-using high-resolution facial images.
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