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Background: There is growing interest in the potential of alternative modes of caffeine administration for enhancing sports performance. Given that alternative modes may evoke improved physical performance via distinct mechanisms, effects may not be comparable and studies directly comparing the erogenicity of alternative modes of caffeine administration are lacking. To address this knowledge gap, the present study evaluated the effect of 3 mg·kg caffeine delivered in anhydrous form via capsule ingestion, chewing gum or mouth rinsing on measures of muscular strength, power, and strength endurance in male Rugby Union players.
Methods: Twenty-seven participants completed the study (Mean ± SD: Age 20 ± 2 yrs; daily caffeine consumption 188 ± 88 mg). Following assessments and reassessment of chest press (CP), shoulder press (SP), Deadlift (DL), and Squat (SQ) 1-repetition maximum (1RM) and familiarization to the experimental procedures, participants completed six experimental trials where they were administered 3 mg.kg caffeine (Caff) or placebo (Plac) capsule, chewing gum or mouth rinse in a randomized, double-blind and counterbalanced fashion prior to force platform assessment of countermovement jump, drop jump and isometric mid-thigh pull performance. Strength endurance was measured across two sets of CP, SP, DL, and SQ at 70% 1RM until failure. Pre-exercise perceptions of motivation and arousal were also determined.
Results: Caffeine increased perceived readiness to invest mental effort ( = .038; ηp=.156), countermovement jump height ( = .035; ηp=.160) and SQ repetitions until failure in the first set ( < .001; d = .481), but there was no effect of delivery mode ( > .687; ηp<.015). Readiness to invest physical effort, felt arousal, drop jump height, countermovement jump, drop jump and isometric mid-thigh pull ground reaction force-time characteristics and repetitions until failure in CP, SP and DL were not affected by caffeine administration or mode of caffeine delivery ( > .0.052; ηp< .136).
Conclusion: 3 mg.kg caffeine administered via capsule, gum or mouth rinse had limited effects on muscular strength, power, and strength endurance. Small effects of caffeine on CMJ height could not be explained by changes in specific ground reaction force-time characteristics and were not transferable to DJ performance, and effects specific to the SQ RTP exercise underpin the complexity in understanding effects of caffeine on muscular function. Novel modes of caffeine administration proposed to evoke benefits via distinct mechanisms did not offer unique effects, and the small number of effects demonstrated may have little translation to a single performance trial when data examining direct comparison of each caffeine vehicle compared against a mode matched placebo is considered.
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http://dx.doi.org/10.1080/15502783.2024.2419385 | DOI Listing |
Cell Commun Signal
September 2025
Department of Cytology, Institute of Anatomy, Medical Faculty, Ruhr-University Bochum, Universitätsstr. 150, Building MA 5/52, Bochum, 44801, Germany.
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by oxidative stress and progressive motor neuron degeneration. This study evaluates the potential neuroprotective effects of caffeine in the Wobbler mouse, an established model of ALS.
Methods: Wobbler mice received caffeine supplementation (60 mg/kg/day) via drinking water, and key parameters, including muscle strength, NAD metabolism, oxidative stress, and motor neuron morphology, were assessed at critical disease stages.
Adv Emerg Nurs J
September 2025
Author Affiliations: Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, University of South Carolina (Dr Weant); and Department of Pharmacy, University of North Carolina Health, Chapel Hill, North Carolina (Dr Gregory).
Migraine is an often-disabling condition and a common presentation to the Emergency Department (ED). Rapid and effective treatment are essential to reduce symptom burden, prevent recurrence, and improve patient outcomes. This review provides a comprehensive, evidence-based overview of the pharmacologic management of acute migraine in the ED, including first-line therapies, rescue medications, adjunctive care strategies, and considerations for special populations.
View Article and Find Full Text PDFJ Behav Addict
September 2025
2Columbia University School of Nursing, New York, NY, USA.
Background And Aims: Caffeine is the most commonly used substance during gaming sessions. Despite health guidelines to avoid caffeine before adulthood, many adolescents use caffeine to compensate for lost sleep or prolong wakefulness to enhance gaming performance. The relationship between gaming and sleep is well-established, but the role of caffeine has been under-explored.
View Article and Find Full Text PDFInt J Sport Nutr Exerc Metab
September 2025
Exercise and Performance Nutrition Laboratory, School of Health Sciences, Lindenwood University, St. Charles, MO, USA.
Caffeine (CAF) mouth rinsing has been considered a practical nutritional strategy among athletes. Recent studies indicate that this nutritional strategy's efficacy may depend on the athlete's prandial state. Therefore, the main aim of the current study is to determine the effect of CAF mouth rinsing on a battery of soccer-specific tests of soccer players in fasted (FST) or fed states (FED).
View Article and Find Full Text PDFInt J Sport Nutr Exerc Metab
September 2025
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
The Union Cycliste Internationale recognizes several mountain biking (MTB) disciplines, including downhill, enduro, cross-country short track, cross-country Olympic, cross-country marathon, and multiday stage racing. Cyclocross is recognized as a separate cycling discipline. Both MTB and cyclocross include cycling on off-road surfaces of varying technicality on specialized bicycles purposed for the respective disciplines.
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