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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223329 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.4315-24 | DOI Listing |
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Prion diseases are rare neurodegenerative disorders that share misfolding of the normal cellular prion protein into disease-causing isoforms known as "prions" as the critical pathophysiological event. Definite diagnosis can only be achieved through neuropathological confirmation. The neuropathological features of prion disease are well described; however, some molecular subtypes are typified by characteristic neuropathological features that are subtle or absent.
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