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Excessive human exposure to toxic gases can lead to chronic lung and cardiovascular diseases. Thus, precise in situ monitoring of toxic gases in the atmosphere is crucial. Here, we present an artificial olfactory system for spatiotemporal recognition of NO gas flow by integrating a network of chemical receptors with a near-sensor computing. The artificial olfactory receptor features nano-islands of metal-based catalysts that cover the graphene surface on the heterostructure of an AlGaN/GaN two-dimensional electron gas (2DEG) channel. Catalytically dissociated NO molecules bind to graphene, thereby modulating the conductivity of the 2DEG channel. For the energy/resource-efficient gas flow monitoring, trust-region Bayesian optimization algorithm allocates many sensors optimally in a complex space. Integrated artificial neural networks on a compact microprocessor with a network of sensors provide in situ gas flow predictions. This system enhances protective measures against toxic environments through spatiotemporal monitoring of toxic gases.
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http://dx.doi.org/10.1126/sciadv.adr2659 | DOI Listing |
ACS Appl Mater Interfaces
September 2025
Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8568, Japan.
Chemical sensor arrays mimic the mammalian olfactory system to achieve artificial olfaction, and receptor materials resembling olfactory receptors are being actively developed. To realize practical artificial olfaction, it is essential to provide guidelines for developing effective receptor materials based on the structure-activity relationship. In this study, we demonstrated the visualization of the relationship between sensing signal features and odorant molecular features using an explainable AI (XAI) technique.
View Article and Find Full Text PDFJ Integr Neurosci
August 2025
Complex Operative Unit (UOC) Otolaryngology-Head and Neck Surgery, Ospedale San Camillo de Lellis, Azienda Sanitaria Locale (ASL) Rieti-Sapienza University, 02100 Rieti, Italy.
Nasal cytology is evolving into a promising tool for diagnosing neurological and psychiatric disorders, especially those such as Alzheimer's and Parkinson's diseases. Moreover, recent research has indicated that biomarkers differ greatly between samples taken before and after death. Nasal cytology might help to identify the early stages of cognitive decline.
View Article and Find Full Text PDFJ Alzheimers Dis
September 2025
Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
BackgroundIndividuals with subjective cognitive decline (SCD) are at high risk of preclinical Alzheimer's disease (AD). While olfactory dysfunction is evident in AD and mild cognitive impairment (MCI), its presence and neural mechanism in SCD remain unclear.ObjectiveThis study examined functional connectivity (FC) alterations across olfactory networks and their mediating role between olfactory and cognitive functions in SCD and MCI.
View Article and Find Full Text PDFJ Mater Chem B
August 2025
UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie thérapeutique, Institut de Biologie et Chimie des Protéines, CNRS/Université Claude Bernard Lyon 1, CEDEX 07, 69367, Lyon, France.
The treatment of brain disorders nose-to-brain delivery (NtBD) is a promising non-invasive strategy to bypass the blood-brain barrier. In this study, we developed and characterized polymeric nanoparticles (NPs) based on polylactic acid (PLA) and poloxamers (P188 and P407), synthesized one-step or two-step nanoprecipitation methods. All formulations resulted in homogeneous, negatively charged NPs with a diameter of 110 nm, compatible with efficient brain delivery.
View Article and Find Full Text PDFCurr Zool
August 2025
Department of Ecology and Biogeography, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, 87-100 Toruń, Poland.
Artificial light at night (ALAN) is a common anthropogenic disturbance, which alters animal behavior. However, little is known about the impact of the spectral composition of ALAN and co-occurring predation risk on the behavior of aquatic organisms. We experimentally investigated how ALAN of different spectra (cool white LED and HPS light) affects the behavior and foraging of (Amphipoda) on chironomid prey, both as a single stressor and in combination with an olfactory predation cue.
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