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Internet of things (IoT) facilitates a variety of heterogeneous devices to be enabled with network connectivity via various network architectures to gather and exchange real-time information. On the other hand, the rise of IoT creates Distributed Denial of Services (DDoS) like security threats. The recent advancement of Software Defined-Internet of Things (SDIoT) architecture can provide better security solutions compared to the conventional networking approaches. Moreover, limited computing resources and heterogeneous network protocols are major challenges in the SDIoT ecosystem. Given these circumstances, it is essential to design a low-cost DDoS attack classifier. The current study aims to employ an improved feature selection (FS) technique which determines the most relevant features that can improve the detection rate and reduce the training time. At first, to overcome the data imbalance problem, Edited Nearest Neighbor-based Synthetic Minority Oversampling (SMOTE-ENN) was exploited. The study proposes SFMI, an FS method that combines Sequential Feature Selection (SFE) and Mutual Information (MI) techniques. The top k common features were extracted from the nominated features based on SFE and MI. Further, Principal component analysis (PCA) is employed to address multicollinearity issues in the dataset. Comprehensive experiments have been conducted on two benchmark datasets such as the KDDCup99, CIC IoT-2023 datasets. For classification purposes, Decision Tree, K-Nearest Neighbor, Gaussian Naive Bayes, Random Forest (RF), and Multilayer Perceptron classifiers were employed. The experimental results quantitatively demonstrate that the proposed SMOTE-ENN+SFMI+PCA with RF classifier achieves 99.97% accuracy and 99.39% precision with 10 features.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486411 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0309682 | PLOS |
Nanoscale
September 2025
Institute of Health Innovation & Technology, National University of Singapore, Singapore, 117599, Singapore.
The rapid increase in multidrug-resistant (MDR) bacteria and biofilm-associated infections has intensified the global need for innovative antimicrobial strategies. Phage therapy offers promising precision against MDR pathogens by utilizing the natural ability of phages to specifically infect and lyse bacteria. However, their clinical application is hampered by challenges such as narrow host range, immune clearance and limited efficacy within biofilms.
View Article and Find Full Text PDFBlood Press Monit
September 2025
Baishan Maternal and Child Health and Family Planning Service Center, Baishan City, Jilin Province, China.
Objective: This study investigated the relationship of maternal serum uric acid, cystatin C (CysC), and coagulation indices [international normalized ratio (INR) and fibrinogen (FIB)] during pregnancy with clinical features and prognosis of early-onset pre-eclampsia.
Methods: Patients with pre-eclampsia (n = 133) were retrospectively selected, with clinical features and maternal uric acid, CysC, INR, and FIB levels collected. The relationship between clinical features and maternal uric acid, CysC, INR, and FIB was analyzed by Pearson's and Spearman's analyses.
Diagn Interv Radiol
September 2025
LMU University Hospital, LMU Munich, Department of Radiology, Munich, Germany.
Purpose: Computed tomography fluoroscopy (CTF)-guided biopsy is an established technique for sampling pulmonary lesions, particularly with the growing prevalence of lung nodule screening programs. This study investigated procedural and lesion-related factors affecting success and complication rates in routine CTF-guided lung core-needle biopsies at a tertiary center.
Methods: Consecutive patients undergoing percutaneous CTF-guided lung biopsies over a 10-year period (2007-2016) were retrospectively analyzed.
J Am Chem Soc
September 2025
Department of Chemistry, University of Zurich, CH-8057, Zurich, Switzerland.
Paraptosis is a distinct form of programmed cell death characterized by cytoplasmic vacuolization, mitochondrial swelling, and endoplasmic reticulum (ER) dilation, offering an alternative to apoptosis for therapeutic applications. In this study, we identified a hemicyanine derivative that is a potent paraptosis inducer in two cancer cell lines. This compound triggers hallmark paraptotic features, including ER swelling, mitochondrial morphological changes, increased superoxide production, and caspase-independent cell death.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
State Key Laboratory of Advanced Materials for Intelligent Sensing & Key Laboratory of Organic Integrated Circuit Ministry of Education & Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science & Institute of Molecular Aggregation Science, Tianjin Univ
The design of efficient and user-friendly methods for nitrite detection is of great significance owing to its critical role in food safety and environmental protection. Herein, we report a novel cobalt single-atom nanozyme (CoN SA) featuring a highly asymmetric CoN coordination environment. This structural configuration stabilizes high-spin Co species and significantly enhances the oxidase-like activity.
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