Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
As a significant variant of the Michael reaction, the 1,6-addition reaction has undergone considerable development over the past decade. This effective strategy enables the synthesis of a variety of novel and potentially bioactive functional molecules. In this review, we summarize the recent progress in NHC-catalyzed 1,6-addition reactions, highlighting their efficiency in the rapid synthesis of complex functional molecules. We also provide our perspectives on the future development of this dynamic and highly active research area.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/tcr.202400125 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reductive N-Heterocyclic Carbene Catalysis via Hydride Transfer: Generating Homoenolates from Unsaturated Esters.
Org Lett
June 2025
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China.
In N-heterocyclic carbene (NHC) catalysis, the reduction of NHC-bound acyl azolium species is achieved with progress limited to the generation of ketyl radical intermediates. Here, we report a novel NHC-catalyzed reductive mode for acyl azolium intermediates, which accept a hydride to generate the Breslow intermediate. Then, the reaction of the Breslow intermediate with chalcone results in the formation of cyclopentene, demonstrating a classic umpolung transformation.
View Article and Find Full Text PDFEnantioselective electrophilic activation of aldehydes, esters and imines N-heterocyclic carbene catalysis.
Chem Commun (Camb)
April 2025
State Key Laboratory of Green Pesticide, Guizhou University, Huaxi District, Guiyang 550025, China.
We summarize in this review the recent key progress in the NHC-catalyzed electrophilic activation of carbonyl compounds for the regioselective functionalization of saccharides, enantioselective construction of heterocycles, and asymmetric synthesis of axially and planar chiral molecules.
View Article and Find Full Text PDFRecent Progress on NHC-Catalyzed 1,6-Conjugate Addition Reactions.
Chem Rec
November 2024
College of Chemistry and Chemical Engineering, Guizhou University of Engineering Science, Xueyuan Road, Qixingguan District, Bijie, 551700, China.
As a significant variant of the Michael reaction, the 1,6-addition reaction has undergone considerable development over the past decade. This effective strategy enables the synthesis of a variety of novel and potentially bioactive functional molecules. In this review, we summarize the recent progress in NHC-catalyzed 1,6-addition reactions, highlighting their efficiency in the rapid synthesis of complex functional molecules.
View Article and Find Full Text PDFCarbene-Catalyzed Asymmetric Construction of Atropisomers.
Angew Chem Int Ed Engl
December 2021
Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
Atropisomeric molecules have found proven applications and have shown promising potential in chemistry and medicine. The design of N-heterocyclic carbene (NHC) catalyzed reactions to construct atropisomerically enriched molecules has emerged as an important research topic in recent years. These reactions include kinetic resolutions, asymmetric desymmetrizations, central-to-axial chirality conversions, and cycloadditions.
View Article and Find Full Text PDFRecent advances in N-heterocyclic carbene-based radical catalysis.
Chem Sci
May 2020
Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University Kakuma-machi Kanazawa 920-1192 Japan
In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the pyruvate decarboxylation. The resultant enamine, a so-called "Breslow intermediate," is known to perform single electron transfer to various electron acceptors. Inspired by this enzymatic catalysis, N-heterocyclic carbene (NHC)-catalyzed radical reactions have been developed.
View Article and Find Full Text PDF