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Background: Achieving successful pain control and adequate anesthesia through an inferior alveolar nerve block for endodontic treatment in cases with symptomatic irreversible pulpitis (SIP) is difficult, especially in mandibular molars. This study was designed to compare the effect of oral medication with ibuprofen and soft laser therapy on inferior alveolar nerve block during endodontic treatment.
Methods: The trial comprised 180 patients (45 each group) with SIP. Four groups of patients were created: group 1 received 400 mg of ibuprofen; group 2 received soft laser irradiation; group 3 received a combination of soft laser and ibuprofen 400 mg; and group 4 received a placebo 1 h prior to local anesthesia. Patients recorded their pain scores on the Heft-Parker visual analog scale (VAS) before the start of intervention, 15 min after anesthesia, during access cavity preparation, and ultimately during root canal instrumentation. Each patient also rated their level of discomfort on a VAS. Every stage with no or minimal discomfort was deemed successful. The chi-square, Kruskal-Wallis, and one-way analysis of variance tests were used to evaluate the data.
Results: The best success rate was achieved for soft laser ibuprofen combination, ibuprofen and soft laser groups reported similar success results, and control group recorded the least pain scores. The mean pain scores were lowest for group 3 and highest for group 4 (P < 0.001). Ibuprofen and soft laser combination was significantly better than control group (P < 0.001). There was no significant difference between ibuprofen and laser groups (P = 0.24).
Conclusion: For teeth with irreversible pulpitis, preoperative ibuprofen treatment combined with soft laser irradiation greatly improved the success rates of inferior alveolar nerve block anesthesia.
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http://dx.doi.org/10.17245/jdapm.2024.24.5.341 | DOI Listing |
Front Oncol
August 2025
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Synovial sarcoma (SS) is one of the most prevalent malignant soft tissue sarcomas in children and adolescents. Pediatric populations often present with atypical features, complicating the differentiation from benign intramuscular venous malformations (VMs).
case Presentation: An 11-year-old male with a four-year history of progressive right plantar pain and a compressible intramuscular mass.
Langmuir
September 2025
Process Engineering in Life Science Engineering, HTW Berlin, Wilhelminenhofstraße 75 A, 12459 Berlin, Germany.
Pickering emulsions (PEs), where water-in-oil (w/o) droplets are stabilized by nanoparticles (NPs), offer a promising platform for biocatalysis by providing a large interfacial area crucial for efficient substrate conversion. While several lipase catalyzed reactions in PEs have been demonstrated, the exact interfacial structure is unknown. This study focuses on the interfacial network formed by NPs and lipase (CRL) at the octanol/water-interface by varying pH and NP charge.
View Article and Find Full Text PDFJ Adv Prosthodont
August 2025
Department of Prosthodontics, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Türkiye.
Purpose: This study evaluated the fit of implant-supported bars fabricated using different computer-aided manufacturing (CAM) techniques.
Materials And Methods: A mandibular model with four dental implants (Nobel Replace Conical Connection, 3.5 mm × 11.
Adv Mater
September 2025
Soft Matter Optics Group, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, Wroclaw, 50-370, Poland.
Nematic Liquid Crystals (LCs), noted for their simple molecular alignment and broad use in optoelectronics, remain unmodified for over a century. However, in 2017, a unique polar phase, the ferroelectric nematic (N), is confirmed. Subsequently, in 2024, the revolutionary spontaneous mirror symmetry breaking of ferroelectric twist-bend nematic chiral structures (N phase) is demonstrated.
View Article and Find Full Text PDFStomatologiia (Mosk)
September 2025
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Objective: To present a retrospective analysis, clinical picture, diagnostic and surgical tactics in the clinical observation of capillary blood vessel malformation.
Unlabelled: The article presents an analysis of a clinical case of capillary malformation in a 17-year-old boy who was admitted to the children's clinic of the Central Research Institute of Dentistry and Maxillofacial Surgery after inadequate, long-term treatment with various treatment methods for capillary-type blood vessel malformations in the lower lip area. Incorrectly chosen treatment tactics led to hypertrophy and scarring of soft tissue in the affected area.