[Clinical observation and complications in the treatment of a child with capillary malformation in the facial area].

Objective: To present a retrospective analysis, clinical picture, diagnostic and surgical tactics in the clinical observation of capillary blood vessel malformation.

Unlabelled: The article presents an analysis of a clinical case of capillary malformation in a 17-year-old boy who was admitted to the children's clinic of the Central Research Institute of Dentistry and Maxillofacial Surgery after inadequate, long-term treatment with various treatment methods for capillary-type blood vessel malformations in the lower lip area. Incorrectly chosen treatment tactics led to hypertrophy and scarring of soft tissue in the affected area.

Parkinson's Disease Multidisciplinary Complex Therapy (PD-MCT): appreciation of its current function for the treatment of people with Parkinson's disease in Germany and the needs of future development.

The inpatient Parkinson's Disease Multimodal Complex Therapy (PD-MCT) is a specialized therapeutic concept for people with Parkinson's disease (PD), that is increasingly applied with great success in Germany. It provides a core element of the provision of care for the more than 400,000 PD patients in Germany. In this expert review, we describe the basic elements of PD-MCT in Germany with its structural features, treatment team, therapeutic process and contents.

The lung proteome in HIV-associated obstructive lung disease.

Rationale: Obstructive lung disease is increasingly common among persons living with HIV (PLWH). There are currently no validated biomarkers that identify individuals at risk of developing obstructive lung disease (OLD), and specific mechanisms contributing to HIV-associated OLD remain elusive, independent of smoking. We sought to identify biomarkers and biological pathways associated with OLD using a broad proteomic approach.

Combined genomics and proteomics unveils elusive variants and vast aetiologic heterogeneity in dystonia.

Dystonia is a rare disease trait for which large-scale genomic investigations are still underrepresented. Genetic heterogeneity among patients with unexplained dystonia warrants interrogation of entire genome sequences, but this has not yet been systematically evaluated. To significantly enhance our understanding of the genetic contribution to dystonia, we (re)analysed 2874 whole-exome sequencing (WES), 564 whole-genome sequencing (WGS), as well as 80 fibroblast-derived proteomics datasets, representing the output of high-throughput analyses in 1990 patients and 973 unaffected relatives from 1877 families.

Increase in EEG functional connectivity and power during wakefulness in self-limited epilepsy with centrotemporal spikes.

Objective: Examine power and functional connectivity (FC) in children with Self-limited Epilepsy with Centrotemporal Spikes (SeLECTS) during resting-state.

Methods: We retrospectively analyzed 37 children with SeLECTS and 34 matched controls. Fifty seconds of awake resting-state source-reconstructed EEG per subject were selected to compare groups using power and weighted phase lag index (wPLI).