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Purpose: The purpose of this study was to determine whether a higher Injury Severity Score (ISS) could serve as an indicator of splenectomy in patients with traumatic splenic lacerations.
Methods: A total of 256 cases of splenic laceration were collected from January 1, 2005 to December 31, 2018. After the application of exclusion criteria, 105 were eligible for this study. Charts were reviewed for demographic characteristics, initial vital signs upon presentation to the emergency room, Glasgow Coma Scale, computed tomography findings, ISS, and treatment strategies. The cases were then divided into nonsplenectomy and splenectomy groups for analysis.
Results: When analyzed with the chi-square test and t-test, splenectomy was associated with a systolic blood pressure lower than 90 mmHg, a Glasgow Coma Scale score lower than 13, active bleeding found on computed tomography, a splenic laceration grade greater than or equal to 4, and an ISS greater than 15 at presentation. However, in multivariate logistic regression analysis, only active bleeding on computed tomography showed a statistically significant relationship (P=0.014).
Conclusions: Although ISS failed to show a statistically significant independent relationship with splenectomy, it may still play a supplementary role in traumatic splenic injury management.
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http://dx.doi.org/10.20408/jti.2021.0065 | DOI Listing |
Georgian Med News
June 2025
5Department of Gynecology and Reconstructive Urology, CNE "Vinnytsia Regional Clinical Hospital Named After M.I. Pirogov Vinnytsia Regional Council", Ukraine.
Aim: To examine how temperature changes over time in injured and uninjured kidney tissues, based on the time elapsed since trauma and death. Additionally, develop a regression model to estimate the time of death using temperature measurements from the abdominal organs.
Material And Methods: The study included data from 256 individuals (both males and females aged 20-60 years) who died from mechanical trauma.
Clin Imaging
October 2025
Division of Interventional Radiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
This retrospective quality assurance review evaluates the concordance between visual intra-procedural angiographic estimates and CT-derived volumetric measurements of splenic embolization using n-butyl cyanoacrylate (n-BCA) with tantalum in 15 patients at a single institution. In this internal audit, 3D-Slicer software was used to segment and calculate splenic volumes from pre- and post-procedure CT scans in a series of cases where n-BCA was used for non-traumatic splenic embolization. The median pre- and post-embolization splenic volumes were 883.
View Article and Find Full Text PDFSci Rep
August 2025
Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
The spleen is the target of numerous non-neoplastic and uncommon neoplastic lesions. Our study's objective was to evaluate the main indications and clinicopathologic features of a large number of splenectomy specimens from southern Iran, with a focus on splenic neoplasms. This five-year retrospective cross-sectional study was carried out on all splenectomy specimens from two referring centers.
View Article and Find Full Text PDFEur J Med Res
August 2025
Department of Hepatobiliary-Pancreatic-Spleen-Gastrointestinal Surgery Surgeon, Lanxi People's Hospital, Jinhua, 321100, Zhejiang Province, China.
Background: The spleen is also the largest lymphoid organ and has important immune and haematopoietic functions. Traumatic splenic rupture often results in haemorrhagic shock and is life-threatening. In the past, total splenectomy was performed for various degrees of splenic injury, which caused great harm to the patient.
View Article and Find Full Text PDFBackground: Traumatic brain injury (TBI) triggers a cascade of neuroinflammatory responses mediated by microglial activation, which significantly contributes to secondary brain damage. While triggering receptor expressed on myeloid cells-1 (TREM-1) is a key inflammatory amplifier, its mechanistic role and therapeutic potential in TBI remain elusive. Thus, this study endeavored to elucidate the exact role of TREM-1 in experimental TBI.
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