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http://dx.doi.org/10.1080/03007995.2024.2393863 | DOI Listing |
RSC Adv
September 2025
Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University P. O. 43713 New Galala Egypt
Isatin (1-indole-2,3-dione) is a privileged nitrogen-containing heterocyclic framework that has received considerable attention in anticancer drug discovery owing to its general biological behavior and structural diversity. This review focuses on isatin-heterocyclic hybrids as a valuable model in the development of new anti-cancer drugs that may reduce side effects and help overcome drug resistance, discussing their synthetic approaches and mechanism of action as apoptosis induction through kinase inhibition. With various chemical modifications, isatin had an excellent ability to build powerful isatin hybrids and conjugates targeting multiple oncogenic pathways.
View Article and Find Full Text PDFPalliat Care Soc Pract
September 2025
Faculty of Health, University of Technology Sydney, Ultimo, NSW, Australia.
Background: Despite high mortality rates in long-term care (LTC), LTC homes continue to struggle to implement a palliative approach to care.
Objectives: The objective of this research was to implement and evaluate the Strengthening a Palliative Approach in Long-Term Care (SPA-LTC; www.spaltc.
Background: Adolescents with autism spectrum disorder (ASD) often experience identity confusion, social difficulties, and internalizing symptoms such as anxiety and depression. Physical activity offers opportunities for peer interaction and teamwork, which may help alleviate negative emotions. This study aims to investigate the pathways through which physical activity influences internalizing problems in adolescents with ASD.
View Article and Find Full Text PDFRev Cardiovasc Med
August 2025
Department of Cardiovascular Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, 030032 Taiyuan, Shanxi, China.
The AMP-activated protein kinase (AMPK) alpha (AMPK) subunit is the catalytic subunit in the AMPK complex and includes both 1 and 2 isoforms. Phosphorylation of upstream kinases at the Thr172 site in the -subunit is critical for AMPK activation. The kinases upstream of AMPK include liver kinase B1 (LKB1), calcium/calmodulin-dependent protein kinase kinase (CaMKK), and transforming growth factor -activated kinase 1 (TAK1).
View Article and Find Full Text PDFThe aim of the present study was to assess the anti-inflammatory effect of hesperidin. The research was conducted by optimizing the hesperidin extraction process from citrus peel powder, followed by characterization and nutrition profiling of citrus peel hesperidin extract. Citrus peel was collected from the local market and dried in a hot air oven.
View Article and Find Full Text PDF