A proposed framework to establish - relationships using gastric digestion models for food research.

digestion methods have been utilized in food research to reduce studies. Although previous studies have related and data, there is no consensus on how to establish an - relationship (IVIVR) for food digestion. A framework that serves as a tool to evaluate the utility and limitations of approaches in simulating processes is proposed to develop IVIVRs for food digestion, with a focus on the gastric phase as the main location of food structural breakdown during digestion. The IVIVR consists of three quantitative levels (A, B, and C) and a qualitative level (D), which relate gastric digestion kinetic data on a point-to-point basis, parameters derived from gastric digestion kinetic data, gastric digestion parameters with absorption or appearance parameters, and and trends, respectively. Level A, B, and C IVIVRs can be used to statistically determine the agreement between and data. Level A and B IVIVRs can be utilized further evaluate the accuracy of the approach to mimic processes. To exemplify the utilization of this framework, case studies are provided using previously published static and dynamic gastric digestion data and animal study data. Future food digestion studies designed to establish IVIVRs should be conducted to refine and improve the current framework, and to improve digestion approaches to better mimic phenomena.