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Residents and their pets may experience aesthetic or health concerns resulting from elevated copper in their drinking water. The United States Environmental Protection Agency Lead and Copper Rule focuses on addressing systemwide corrosion issues, but gaps in the rule leave some municipal water consumers and residents with private well water vulnerable to high cuprosolvency. We developed guidance to aid residents in understanding, detecting, and addressing cuprosolvency issues in their drinking water. Three types of at-home test kits for copper and one for pH were determined to be accurate enough ( > 0.9 (lab, based on average values from = 5 replicates each) and >0.7 (field)) to detect concerns related to high cuprosolvency and inform selection of intervention options. Case study results indicate that, although water treatments such as increasing pH on-site may be effective, long-term treatment (>36 weeks or permanently) may be needed to maintain reductions in cuprosolvency. A decision tree is provided to help residents and citizen scientists navigate these concerns for both public water systems and private wells.
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http://dx.doi.org/10.1021/acsestwater.4c00447 | DOI Listing |
Cell Commun Signal
September 2025
Department of Cytology, Institute of Anatomy, Medical Faculty, Ruhr-University Bochum, Universitätsstr. 150, Building MA 5/52, Bochum, 44801, Germany.
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by oxidative stress and progressive motor neuron degeneration. This study evaluates the potential neuroprotective effects of caffeine in the Wobbler mouse, an established model of ALS.
Methods: Wobbler mice received caffeine supplementation (60 mg/kg/day) via drinking water, and key parameters, including muscle strength, NAD metabolism, oxidative stress, and motor neuron morphology, were assessed at critical disease stages.
Regul Toxicol Pharmacol
September 2025
Lincoln University, Lincoln, New Zealand.
The red seaweeds, Asparagopsis taxiformis and A. armata inhibit methane production in ruminants, considered to be mediated by bromoform. This review examines the toxicology, metabolism, epidemiology and pharmacology of bromoform.
View Article and Find Full Text PDFChemosphere
September 2025
Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 9 Strzody Street, 44-100 Gliwice, Poland. Electronic address:
Perchlorate contamination is a recent and significant issue in the context of environmental pollution. Perchlorates are mainly used as ingredients in solid propellants and pyrotechnic compositions. Perchlorate contamination of drinking water and food has recently become a human health concern, as studies have shown that they can interfere with the normal uptake of iodine by the thyroid gland, leading to a reduction in its production of triiodothyronine (T3) and thyroxine (T4) in vertebrates.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Data Science, City University of Hong Kong, Hong Kong, SAR, China.
Background: Water hardness, which refers to the level of dissolved calcium and magnesium salts, is of significant public health concern due to its potential impact on health. The association between water hardness and digestive diseases remains underexplored, with limited evidence from small-scale clinical studies. Given the rising prevalence of digestive disorders worldwide, large-scale cohort studies are needed to address this gap in the literature.
View Article and Find Full Text PDFJ Oral Pathol Med
September 2025
Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent head and neck cancers. The 4-nitroquinoline 1-oxide (4NQO) mouse model of oral carcinogenesis is a well-established model to investigate the mechanism behind OSCC development, including epigenetic alterations. Studies have shown that histone acetylation is a key regulator of gene expression and may play a role in such a tumor.
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