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A 13-year-old male presented with a 2-year history of recurrent aphthous stomatitis. The patient had undergone several unsuccessful treatments, leading to the decision to initiate apremilast. He showed a good clinical response with reduction in outbreaks, and no adverse effects were observed. This is the first report, to our knowledge, of a pediatric patient treated with apremilast for this indication.
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http://dx.doi.org/10.1111/pde.15711 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Stomatology, Taikang Tongji (Wuhan) Hospital, Wuhan, Hubei Province, P.R. China.
Previous studies have suggested potential associations between some dietary factors and oral mucosal lesions (OMLs), however, existing research could be biased due to limited sample size and unaccounted confounding factors. This study aimed to explore the causal relationships between 13 common dietary factors and 3 OMLs using 2-sample Mendelian randomization (MR) analysis. Data for the MR analysis were extracted from publicly available genome-wide association study statistics.
View Article and Find Full Text PDFFront Oral Health
August 2025
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Balance of the oral-intestinal axis microbiota is essential for maintaining oral mucosal health. The occurrence of oral disease is closely linked to the microbiota, this disorder is closely related to the pathogenesis of oral mucosal diseases, such as oral lichen planus, recurrent aphthous ulcer, oral candidiasis and squamous-cell carcinoma. As a microorganism that is beneficial to host health, probiotics can show multi-dimensional therapeutic effects in oral mucosal diseases by targeting and regulating the immune microenvironment of the oral mucosa, inhibiting the colonization of pathogenic bacteria and repairing the barrier function.
View Article and Find Full Text PDFIr J Med Sci
September 2025
Department of Oral Medicine, Cork University Dental School & Hospital, University College Cork, Wilton, T12 E8YV, Cork, Ireland.
Background: Social media is increasingly utilised as a means of disseminating oral health information. Recurrent aphthous stomatitis (RAS) is the most common ulcerating condition of the oral mucosa.
Aim: The aim of this study was to evaluate the quality of TikTok videos concerning RAS.
World J Methodol
September 2025
Department of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Cagliari 09124, Italy.
Recurrent aphthous stomatitis (RAS) is a very frequent condition in developed countries whose basic symptom is a lesion referred to as an aphthous ulcer. High levels of interleukin (IL)-1 and IL-6 and low salivary levels of IL-10 are the basis of RAS pathogenesis. Sublingual supplements based on IL-10 can be very useful in reducing the phenomenon of aphthous recurrence in patients with RAS.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.
Recurrent aphthous stomatitis (RAS) is the most common ulcerative disorder of the oral cavity, although its etiology is still unknown. The present study aimed to identify the proteomic profile associated with the RAS inflammatory process, thereby enhancing our understanding of its etiopathogenesis. We compared salivary protein profiles of RAS patients during an active episode of oral ulceration (30 patients, mean age 36.
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