Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis.

World J Methodol

Department of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Cagliari 09124, Italy.

Published: September 2025


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Article Abstract

Recurrent aphthous stomatitis (RAS) is a very frequent condition in developed countries whose basic symptom is a lesion referred to as an aphthous ulcer. High levels of interleukin (IL)-1 and IL-6 and low salivary levels of IL-10 are the basis of RAS pathogenesis. Sublingual supplements based on IL-10 can be very useful in reducing the phenomenon of aphthous recurrence in patients with RAS. An observational clinical experience with a group of 5 patients with RAS receiving a commercially available IL-10-based supplement was reported by the authors. The findings revealed a subsequent reduction in the incidence of mouth ulcers.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948208PMC
http://dx.doi.org/10.5662/wjm.v15.i3.99176DOI Listing

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