Article Synopsis
- Aging leads to a gradual loss of gray matter in the brain, which is observed in both humans and chimpanzees, providing insights into evolutionary perspectives on brain aging.
- The study introduces a framework comparing gray matter loss with age and cerebral expansion in both species.
- Findings indicate that while humans show a positive link between brain aging and cortical growth, this relationship is absent in chimpanzees, especially in regions tied to advanced cognitive functions, supporting the "last-in-first-out" theory of brain maturation in human evolution.
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Article Abstract
Aging is associated with progressive gray matter loss in the brain. This spatially specific, morphological change over the life span in humans is also found in chimpanzees, and the comparison between these great ape species provides a unique evolutionary perspective on human brain aging. Here, we present a data-driven, comparative framework to explore the relationship between gray matter atrophy with age and recent cerebral expansion in the phylogeny of chimpanzees and humans. In humans, we show a positive relationship between cerebral aging and cortical expansion, whereas no such relationship was found in chimpanzees. This human-specific association between strong aging effects and large relative cortical expansion is particularly present in higher-order cognitive regions of the ventral prefrontal cortex and supports the "last-in-first-out" hypothesis for brain maturation in recent evolutionary development of human faculties.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352902 | PMC |
| http://dx.doi.org/10.1126/sciadv.ado2733 | DOI Listing |
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