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Objectives: This study compared the whitening effect, microhardness, and enamel surface alterations of over-the-counter (OTC) tooth bleaching products with those of a dentist-prescribed at-home bleaching agent.
Materials And Methods: The products available on a popular online marketplace were comprehensively searched and then rated using a specific formula. The effects of the lowest-rated OTC agent (LRA) and the highest-rated OTC agent (HRA) were compared with those of a dentist-prescribed bleaching agent (DPA) on the enamel of extracted human teeth. The bleaching efficacy, post-bleaching microhardness changes, and morphological alterations were assessed by spectrophotometric analysis, Vickers hardness testing, and scanning electron microscopy (SEM) respectively. Statistical analyses included one-way ANOVA and post hoc tests, maintaining a significance level of P < 0.05.
Results: The search of the online marketplace revealed 15 products. The LRA (Teeth Whitening Serum Gel, GEN, China) and the HRA (Bright White-Lovely Smile Premium Teeth Whitening strips, Ray of Smile, USA) were identified on the basis of their ranking. DPA resulted in significantly better tooth whitening than did LRA. The enamel microhardness was lower in the LRA treatment group (14.2%) than in the control and HRA treatment groups (8.84% and 7.26%, respectively). LRA also caused severe topographical alterations to the enamel.
Conclusion: Compared with the poorly rated product, the dentist-prescribed tooth bleaching product resulted in greater colour improvement, less microhardness reduction, and surface changes. The highest-rated product was comparable with the dentist-prescribed agent in this study.
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http://dx.doi.org/10.1038/s41405-024-00253-0 | DOI Listing |
Front Pharmacol
August 2025
Warszawski Uniwersytet Medyczny, Warsaw, Poland.
Objective: The study aimed to analyse purchasing trends of pharmacological products used in allergy management based on data from in-person pharmacy sales across Poland.
Materials And Methods: The research involved an analysis of the sales of pharmacological agents used to alleviate symptoms of localized and systemic allergic skin reactions. The data were collected from a nationwide sample of 6,500 brick-and-mortar pharmacies over the period from 2020 to 2023.
Int J Mol Sci
August 2025
Mediprobe Research Inc., London, ON N5X 2P1, Canada.
The expanding literature on nutraceuticals for male androgenetic alopecia (AGA) has inadvertently created knowledge gaps on the relative efficacy of conventional and non-conventional over-the-counter (OTC) treatments. We conducted a Bayesian network meta-analysis (NMA); the outcome measure was the 24-week change in total hair density (INPLASY202570087). We determined the relative efficacy of nine active comparators-including topical minoxidil 5% and 2%.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
School of Basic Medical Sciences/School of Medical Humanities, Guizhou Medical University, Guiyang 550025, China.
Fenton oxidation technology utilizing hydrogen peroxide is recognized as an effective method for producing reactive oxygen species (ROS) to facilitate the degradation of antibiotics. However, the requirement for strongly acidic conditions during this process significantly restricts its broader applicability. In this study, we synthesized black phosphorus (BP) nanosheets by exposing the {010} crystal planes and then constructed a 0D/2D BP/BiMoO (PBMO) heterojunction to function as a Fenton catalyst.
View Article and Find Full Text PDFInt J Risk Saf Med
August 2025
National Drug Dependence Treatment Centre, AIIMS, New Delhi, India.
BackgroundThere is growing concern about the misuse of Over-the-counter (OTC) medications around the world. Pheniramine is a first-generation antihistamine, which is widely available and is commonly used for allergic conditions. Initially considered to be a safe anti-allergic agent, growing evidence suggests its potential for misuse and dependence.
View Article and Find Full Text PDFAnal Methods
August 2025
School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Tetracycline antibiotic residue in food is of vital significance for public health. Hexagonal boron nitride (h-BN)-based materials are excellent absorbents for antibiotics, and modification of the h-BN surface would improve its adsorption ability. In this study, a FeO-modified h-BN nanocomposite (FeO@h-BN) was fabricated by a simple one-step coprecipitation method.
View Article and Find Full Text PDF