Comparative Effect of Conventional and Non-Conventional Over-the-Counter Treatments for Male Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis.

The expanding literature on nutraceuticals for male androgenetic alopecia (AGA) has inadvertently created knowledge gaps on the relative efficacy of conventional and non-conventional over-the-counter (OTC) treatments. We conducted a Bayesian network meta-analysis (NMA); the outcome measure was the 24-week change in total hair density (INPLASY202570087). We determined the relative efficacy of nine active comparators-including topical minoxidil 5% and 2%.

Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System.

Background: The United States Food and Drug Administration (FDA) approved oral finasteride for androgenetic alopecia. In 2022, approximately 2.6 million U.

Trichophyton indotineae: Epidemiology, antifungal resistance and antifungal stewardship strategies.

There has been a recent shift in the epidemiology of superficial fungal infections (tinea, dermatophytosis, dermatomycoses). Trichophyton indotineae is an emerging dermatophyte species of significant global concern for its contagious nature and antifungal drug resistance. This scoping review includes available clinical and laboratory assessments of T.

Examining the Relationship Between Alopecia Areata and Mental Health: An Investigation of the Global Burden of Disease Study 2021.

Background: Alopecia areata (AA), an autoimmune hair loss disorder, can significantly alter a person's appearance and cause emotional distress. This disorder has been linked to anxiety and depression, but most work has been done on either one-population samples or has been conducted using heterogeneous populations, potentially skewing results.

Aims: We aim to obtain a better understanding of the relationship of AA with anxiety and depression in more finely divided populations based on sex, age, and country.

Comparative Efficacy of Minoxidil and 5-Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta-Analysis Study of Current Empirical Evidence.

Background: Treatment options for male androgenetic alopecia (AGA) range from pharmacologic agents-such as minoxidil, finasteride, and dutasteride-to newer procedural and experimental therapies.

Aims: We determined the relative effect of the various dosages and administrative routes of minoxidil, finasteride and dutasteride through network meta-analysis (NMA) of relevant outcome measures.

Methods: We conducted a systematic review to identify eligible studies.

Do Non-Prescription Products Help in Managing Androgenic Alopecia?

Background: Androgenetic alopecia (AGA) is the most common cause of hair loss. Currently, approved medications for AGA are topical minoxidil and oral finasteride, both of which are prescription medications which may cause side effects. Non-prescription products such as herbal extracts and over-the-counter medications have limited evidence regarding safety and efficacy; however, they may be an alternative for patients unable or unwilling to use prescription medication.

A network meta-analysis study of monotherapies for hidradenitis suppurativa: analyses of the current evidence base.

Background: The number of monotherapies for hidradenitis suppurativa (HS) has expanded. However, the efficacy of active comparators has not been determined in head-to-head trials.

Aims: We conducted an NMA to determine the relative efficacy and safety of monotherapies for HS.

Advances in the treatment of male androgenetic alopecia: current options and emerging therapies.

Introduction: Androgenetic alopecia (AGA), or pattern hair loss, is the most common form of hair loss worldwide. It is primarily caused by genetic and hormonal factors, particularly the action of dihydrotestosterone (DHT) on hair follicles.

Evidence Acquisition: A comprehensive literature search on PubMed and Google Scholar was conducted until October 31, 2024, using keywords related to male AGA and its treatments.

The Relative Efficacy and Safety of Monotherapies for Alopecia Areata: A Network Meta-Analysis Study.

Background: Scant evidence exists for the relative efficacy of therapies for alopecia areata (AA)-including those approved by the Food and Drug Administration, namely, baricitinib, deuruxolitinib, and ritlecitinib.

Aims: We determined the relative efficacy and safety of monotherapy with janus kinase inhibitors (JAKIs), apremilast, and dupilumab.

Methods: Following a systematic review, we conducted Bayesian network meta-analysis (NMAs) that produced Surface Under the Cumulative RAnking (SUCRA) values and point estimates for pairwise relative effects; we also performed sensitivity analyses.

Global Dermatophyte Infections Linked to Human and Animal Health: A Scoping Review.

Dermatophytes are commonly encountered pathogens in clinical practice causing superficial infections of the skin, hair, and nails. These pathogens are often found on animals such as livestock (e.g.

The impact of cannabis use on local anesthetic dosing during hair restoration surgery: a case report, proposed mechanisms, and clinical recommendations.

Cannabis use has increased significantly in the last decade. This article presents a case where a patient needed more local anesthetic (LA) than usual to induce effective anesthesia during hair transplant surgery. The reason cannabis users often need more LA is poorly understood.

Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review.

Introduction: Alopecia affects many individuals, with androgenetic alopecia (AGA) being the most common form in both men and women. The exact etiology of AGA is unclear. The systemic treatments of AGA include 5-alpha reductase inhibitors (finasteride, dutasteride) and low-dose oral minoxidil.

Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on "Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. 2024, , 577".

We find the comment on the article titled "Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective" informative and wish to thank the authors for their added insight on this complex topic [...

The Role of Patient- and Drug-Related Factors in Oral Minoxidil and Pericardial Effusion: Analyses of Data From the United States Food and Drug Administration Adverse Event Reporting System.

Background: While oral minoxidil (OM) has been associated with pericardial effusion (PE), its etiology is presently inconclusive.

Aims: We characterized patient- and drug-related factors across reports from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) for PE and OM.

Methods: Our observation period spanned 18.

Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet-Rich Plasma: A Literature Review.

Background: There are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet-rich plasma represents an abundant source of exosomes.

Aim: To present evidence on the use of platelet-rich plasma-derived exosomes in dermatology and discuss current technical limitations.

Low-Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System (FAERS) With a Focus on Pericardial Effusions.

Background: Low-dose oral minoxidil (LDOM) is used to treat hair loss, but the literature on its safety profile is relatively sparse.

Aims: Using the FDA Adverse Event Reporting System (FAERS) database, we determined signals for adverse events (AEs) with LDOM use.

Methods: Four sets of case/noncase study disproportionality analyses were conducted to determine reporting odds ratio (ROR) for 10 AEs including pericardial effusion (PE).

Antifungal resistance in dermatophytes - review of the epidemiology, diagnostic challenges and treatment strategies for managing infections.

Introduction: There is an increasing number of reports of infections. This species is usually poorly responsive to terbinafine.

Areas Covered: A literature search was conducted in May 2024.

The Comparative Effects of Monotherapy with Topical Minoxidil, Oral Finasteride, and Topical Finasteride in Postmenopausal Women with Pattern Hair Loss: A Retrospective Cohort Study.

Introduction: Oral finasteride and topical minoxidil are long-standing androgenetic alopecia (AGA) treatments; topical finasteride is a more recent medicine. Few studies have compared their therapeutic effects in postmenopausal women. We compared the therapeutic impact of topical finasteride (1-4 sprays of 0.

Comparison of therapeutic agents' short-term effects on facial and scalp actinic keratosis: A network meta-analysis.

Background: Care for actinic keratosis (AK) can be improved with more knowledge on the relative of effect of indicated therapies.

Objectives: Using network meta-analyses, we quantitatively determined the comparative "short-term" effects of interventions in adults with facial and scalp AK.

Methods: On February 28, 2023, evidence from the peer-reviewed literature was systematically obtained from OVID, the Cochrane Central Register of Controlled Trials and ClinicalTrials.

A bibliometric analysis of alternative drug therapy options in the treatment of androgenetic alopecia.

Background: Oral finasteride and topical minoxidil formulations are the only FDA-approved drug therapies for androgenetic alopecia (AGA). Research into dutasteride, topical finasteride, and nontopical minoxidil (low-dose oral and sublingual) formulations in the treatment of AGA has spiked within recent years. Early findings show that these alternative drug therapies may have similar to improved efficacy and safety profiles relative to the conventional treatment options.