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Trivalent SARS-CoV-2 virus-like particle vaccines exhibit broad-spectrum neutralization and protection against XBB.1 and BA.2.86 variants. | LitMetric

Trivalent SARS-CoV-2 virus-like particle vaccines exhibit broad-spectrum neutralization and protection against XBB.1 and BA.2.86 variants.

Virol Sin

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; Guangzhou National Laboratory, Guangzhou, Guangdong,

Published: October 2024


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Article Abstract

• RBDs of the WT, BQ.1.1 and XBB.1 variants were genetically fused and displayed on the VLP to create RBDV14 ​M. • RBDV14 ​M can induce superior antibody responses against the newly emerged SARS-CoV-2 variants XBB.1, EG.5 and BA.2.86. • RBDV14 ​M is one of the few existing next-generation vaccine candidates that utilize virus-like particle platform.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738757PMC
http://dx.doi.org/10.1016/j.virs.2024.08.005DOI Listing

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