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Introduction: Traditional/ritual/medical circumcision can be associated with considerable intraoperative blood loss and a prolonged postoperative healing course. This study investigated the feasibility of the magnetic compression technique (MCT) for circumcision in beagle dogs.
Methods: A set of magnetic rings including a daughter magnetic ring (DMR) and a parent magnetic ring (PMR) were designed for circumcision. In eight beagle dogs as the animal model, the DMR was placed between the penis and the foreskin through the glans, and then the PMR was placed outside the penis. The DMR and PMR automatically attracted together to compress the foreskin. The necrosis of the prepuce of the anterior penis was observed daily. The operation time and time to magnetic ring shedding were recorded. Healing of the foreskin stump was visually observed.
Results: The magnetic rings were successfully installed in all eight dogs, and the operation process was without complication. The average operation time was 3.13 ± 0.92 min (range, 2-4.5 min). Postoperative X-rays showed good attraction of the magnetic rings. Daily post-operative observation showed progressive ischemic necrosis of the anterior foreskin and mild edema of the proximal foreskin. The dogs were generally in good condition and urinated freely. The magnetic rings fell off spontaneously 8-12 days after the operation, and the stump of the foreskin healed well.
Conclusion: The MCT may be a new approach for circumcision in a canine model, which suggests its potential for use in humans.
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http://dx.doi.org/10.1016/j.heliyon.2024.e35646 | DOI Listing |
Nucleic Acids Res
August 2025
Institute for Molecular Biosciences and Center of Magnetic Resonance (BMRZ), Goethe-University Frankfurt, Max-von-Laue Straße 9, 60438 Frankfurt, Germany.
Recently, a novel tobramycin-responsive riboswitch was developed by a combination of Capture-SELEX and in vivo screening. This riboswitch regulates translation initiation in eukaryotes with a high dynamic range and remarkable ligand affinity and selectivity. Its secondary structure differs from all previously described aminoglycoside-binding RNA motifs, suggesting a novel mode of ligand recognition.
View Article and Find Full Text PDFChem Sci
August 2025
Department of Applied Chemistry, School of Science and Technology, Meiji University 1-1-1 Higashimita, Tama-ku Kawasaki Kanagawa 214-8571 Japan
Herein, we report the synthesis and characterization of π-conjugated macrocycles, with diameters over 2.4 nanometers, composed of biphenylene and butadiyne units. Specifically, biphenylene-2,7-diyl-butadiyne-1,4-diyl (BB) macrocycles were synthesized the intermolecular Hay coupling reaction of a 2,7-diethynylbiphenylene derivative.
View Article and Find Full Text PDFDalton Trans
September 2025
University of Patras, Department of Chemistry, 26504 Patras, Greece.
With the aim of assessing the role and impact of pseudohalides on the molecular and supramolecular structures of copper(II)/heavily substituted imidazole complexes, the synthesis and characterization of the complexes {[Cu(N)(HL)]} (1), {[Cu{N(CN)}(HL)]·MeCO} (2·MeCO) and [Cu(NCO)(HL)]·MeCN (3·MeCN) have been carried out; HL is the 4,5-diphenylimidazole ligand. The organic molecule behaves as a monodentate ligand through the pyridine-type nitrogen atom of the imidazole ring. The 1D polymer 1 is made up of undulating {-Cu-(N)-Cu-(N)-} chains, with the HL ligands extending from both sides of the chains.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China.
Selective removal of aromatic contaminants from water matrices poses substantial difficulties in environmental remediation processes, necessitating sophisticated materials with discriminatory molecular recognition properties. Herein, we report a framework-elastomer hybrid membrane containing [Co(4-pmntd)(NO)] (4-pmntd represents ,'-bis(4-pyridylmethyl)naphthalene diimide) designed for effective toluene recovery from trace aqueous environments. Systematic structural analysis employing crystallographic diffraction, gas adsorption measurements, surface electron spectroscopy, and proton nuclear magnetic resonance elucidates the material's architectural characteristics and surface phenomena.
View Article and Find Full Text PDFSurg Radiol Anat
August 2025
Department of Neuroendovascular Therapy, Saitama Sekishinkai Hospital, 2-37-20 Irumagawa, Sayama, Saitama, 350-1305, Japan.
Purpose: To describe a case of two arterial rings of the anterior cerebral artery (ACA)-the anterior communicating artery (ACoA) complex diagnosed by magnetic resonance angiography (MRA).
Methods: A 72-year-old woman with a brain tumor underwent cranial magnetic resonance imaging (MRI) and MRA using a 3-Tesla scanner. MRA was performed using a standard 3-dimensional time-of-flight technique.