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Nonobstructive azoospermia (NOA) is considered the most challenging clinical scenario for infertile men and current treatments leave many men unsuccessful at being able to achieve a pregnancy with their partner using their own sperm. Microdissection testicular sperm extraction (micro-TESE) is the choice for men with NOA desiring to father children with their own gametes. Micro-TESE results in the highest numbers of sperm cells retrieved for use with in vitro fertilization/intracytoplasmic sperm injection. With suboptimal micro-TESE success rates of sperm retrieval and then pregnancy and live birth using the retrieved sperm with in vitro fertilization/intracytoplasmic sperm injection, advances to improve outcomes are necessary. This article comprehensively reviews the technologies investigated to date to improve the outcomes for men undergoing micro-TESE.
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http://dx.doi.org/10.4103/aja202450 | DOI Listing |
J Acoust Soc Am
September 2025
NATO Centre for Maritime Research and Experimentation, La Spezia 19126, Italy.
The Atlantification of the Arctic is driving a northward habitat shift of many cetaceans, including sperm whales (Physeter macrocephalus). As Arctic warming continues to decrease sea ice extent and contributes to the change in species distributions, it is crucial to study how the distribution patterns, habitat, and the demographic structure of sperm whale populations may continue to change. In this study, we assess the temporal presence of echolocating sperm whales on the continental slope southwest of the Svalbard archipelago and compare it with acoustic backscatter and temperature as a proxy for biomass.
View Article and Find Full Text PDFZool Res
September 2025
Department of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China. E-mail:
Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I; however, the precise mechanisms regulating these processes remain poorly understood. Our previous work demonstrated that deletion of heat shock factor 5 (HSF5), a member of the heat shock factor family, induces meiotic arrest and male infertility. However, the molecular pathways through which HSF5 governs meiotic progression have not yet been fully elucidated.
View Article and Find Full Text PDFReprod Domest Anim
September 2025
Department of Teaching Veterinary Clinical Complex, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.
The present study was undertaken to assess the effect of kisspeptin supplementation (0.0, 5.0, 10.
View Article and Find Full Text PDFCurr Opin Urol
September 2025
Department of Urology.
Purpose Of Review: Infertility affects approximately 15% of couples, with male factors implicated in more than 50% of cases. Concerns over declining semen quality - evidenced by a more than 50% drop in sperm concentration over four decades - have triggered investigation into modifiable lifestyle and environmental factors. This review summarizes recent evidence on exposures that negatively impact male fertility.
View Article and Find Full Text PDFJ Mol Histol
September 2025
Department of Anatomical Sciences and Cognitive Neuroscience, TMS.C., Islamic Azad University, Tehran, Iran.