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Article Abstract
Highly strained [3.2.1] bicyclic twisted amide and corresponding amidium were synthesized for the first time through Ag(I)-mediated halide abstraction. After initial lactamization attempts failed, a second-generation strategy was devised to target amidium via intramolecular alkylation. The 3,4-dihydroisoquinolone cyclization precursor was regioselectively prepared via a Rh(III)-catalyzed C-H activation/annulation reaction. After Ag(I)-assisted cyclization, the [3.2.1] bicyclic framework of amidium was confirmed by X-ray crystallography and enabled full solution characterization of twisted amide .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11382264 | PMC |
| http://dx.doi.org/10.1021/acs.joc.4c01192 | DOI Listing |
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