Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Vitexin is a natural flavonoid compound extracted from Vitex leaves or seeds, exhibiting various pharmacological activities including anticancer, antihypertensive, anti-inflammatory, and spasmolytic effects. However, its protective effects on hypertensive nephropathy (HN) and the underlying mechanisms remain unclear.
Methods: Spontaneous hypertension rats were fed a high-sugar and high-fat diet for 8 weeks to induce the disease HN model. From the 5th week, the rats were administered vitexin via gavage. Blood pressure was measured biweekly using the tail-cuff method. Histopathological changes were assessed using HE staining, and biochemical analyses were performed to evaluate the effects of vitexin on HN rats. The underlying mechanisms of vitexin treatment were investigated through western blotting.
Results: The data demonstrated that vitexin significantly lowered systolic, diastolic, and mean arterial pressures and ameliorated histopathological changes in HN rats. Biochemical analyses revealed that vitexin reduced the levels of creatinine (Cr), blood urea nitrogen (BUN), total cholesterol (TC), triglycerides (TG), total protein (TP), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA), and advanced glycation end products (AGEs), while increasing the levels of albumin (ALB) and superoxide dismutase (SOD). Western blotting results indicated that vitexin treatment decreased the expression of TNF-α, IL-6, and nuclear factor kappa-B (NF-κB), while increasing the expression of SOD.
Conclusion: The findings of this study suggest that vitexin exerts protective effects against HN, providing pharmacological evidence for its potential use in HN treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000540618 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protein profiles and associated biological pathways among different etiologies of chronic kidney disease: new insights from DAPA-CKD.
Nephrol Dial Transplant
September 2025
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Background: We investigated circulating protein profiles and molecular pathways among various chronic kidney disease (CKD) etiologies to study its underlying molecular heterogeneity.
Methods: We conducted a proteomic biomarker analysis in the DAPA-CKD trial recruiting adults with and without type 2 diabetes with an eGFR of 25 to 75 mL/min/1.73m2 and a UACR of 200 to 5000 mg/g.
Identification of Potential Urine Biomarkers of Hypertensive Nephropathy for Predicting Disease Progression Based on Metabolomics and Peptidomics.
J Proteome Res
September 2025
Department of Intensive Care Unit, Hangzhou Geriatric Hospital, Hangzhou 310022, China.
Hypertensive nephropathy (HN) complicates hypertension with subtle early symptoms, hindering diagnosis. To address this, an integrated urinary metabolomics and peptidomics analysis was conducted comparing HN patients to hypertensive (HTN) controls, aiming to identify molecular signatures indicative of disease progression and clarify the pathophysiological mechanisms driving HN development. Urine samples were analyzed from both discovery (51 HTN vs 51 HN patients, including 27 early stage and 24 advanced-stage) and validation (21 HTN vs 21 HN) cohorts.
View Article and Find Full Text PDF4-Hydroxychalcone alleviated Angiotensin II-induced atrial fibrillation via immunoproteasome-IKK-NF-κB signaling pathway modulation.
J Mol Med (Berl)
August 2025
Institute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, No.826, South West Road, Shahekou District, Dalian, 116089, China.
Atrial Fibrillation (AF) is the most common type of cardiac arrhythmia and a significant contributor to stroke occurrence. Although 4-Hydroxychalcone (4HCH) has notable anti-inflammatory and antioxidant properties, playing critical therapeutic roles in hypertensive nephropathy and cardiac remodeling, its effects on AF are somewhat unclear, thus forming the basis of this study. Herein, AF was induced in mice via continuous infusion of Angiotensin II (Ang II) at a dose of 2000 ng/kg/min for three weeks.
View Article and Find Full Text PDFApplication of serum STIM1, AOPPS, and urinary NGAL, AGT in the diagnosis of hypertensive nephropathy.
Ren Fail
December 2025
Department of General Practice, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Objective: We aim to explore the diagnostic value of early detection of serum stromal interaction molecule 1 (STIM1), advanced oxidation protein products (AOPPs), urinary neutrophil gelatinase-associated lipocalin (NGAL), and angiotensinogen (AGT) in hypertensive nephropathy (HN).
Methods: A retrospective study was conducted on 123 patients with primary hypertension. Based on the diagnostic criteria for HN, patients were divided into the HN group ( = 58) and simple hypertension group ( = 65).
Rehmannioside A alleviates renal inflammation and fibrosis in hypertensive nephropathy via AT1R/MAPK14/IL-17 signaling pathway.
Biochem Biophys Res Commun
August 2025
The Department of Geriatric, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250001, PR China. Electronic address:
Background: This study aimed to observe the influences and potential mechanism of rehmannioside A (ReA) in hypertensive nephropathy (HN).
Methods: HN model in mice and rat tubular epithelial cells were constructed by angiotensin II (Ang II). The biomarkers of renal function, including uric acid (UA), creatinine (Cre), blood urea nitrogen (BUN), and urine albumin, were assessed.