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Article Abstract
Overexpression of carboxyl/cholinesterase (CCE) genes has been reported to be associated with many cases of pesticide resistance in arthropods. However, it has been rarely documented that genes participate in spirodiclofen resistance in . In previous research, we found that spirodiclofen resistance is related to increased P450 and CCE enzyme activities in . In this study, we identified two genes, and , which were significantly upregulated in spirodiclofen-resistant strain and after exposure to spirodiclofen. RNA interference of and increased the spirodiclofen susceptibility in . In vitro metabolism indicated that CCE3 and CCE5 could interact with spirodiclofen, but metabolites were detected only in the CCE3 treatment. Our results indicated that CCE3 participates in spirodiclofen resistance through direct metabolism, and CCE5 may be involved in the spirodiclofen resistance by passive binding and sequestration, which provides new insights into spirodiclofen resistance in .
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