Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The role of endoscopic mucosal resection (EMR) for laterally spreading lesions (LSLs) in inflammatory bowel disease (IBD) remains controversial despite its effectiveness in the general population. We aimed to characterize outcomes of EMR for IBD-associated LSLs compared with controls without IBD.
Methods: We performed a retrospective observational cohort study of patients with IBD who underwent EMR and endoscopic follow-up for LSLs, compared with a control group without IBD. The primary outcome was histologic recurrence. Secondary outcomes included en bloc resection and adverse events. Factors associated with recurrence were identified using multivariate mixed effects logistic regression.
Results: 210 premalignant lesions in 155 patients were included. By histology, 91.0% were adenoma/low grade dysplasia or sessile serrated lesions. Median (IQR) lesion size was 25 (12-30) mm in the IBD group and 20 (12-30) mm in the control group. Recurrence was detected in 30.4% of IBD-associated lesions (7/23) compared with 20.9% of controls (39/187; odds ratio [OR] 2.51, 95%CI 0.59-10.71). En bloc resection was less common in the IBD group (2/23 [8.7%], 95%CI 1.1-28.0) versus controls (106/187 [56.7%], 95%CI 50.4-65.2). After adjusting for lesion size and histology, recurrence appeared more common in patients with IBD compared with controls (OR 3.08, 95%CI 1.04-9.13).
Conclusions: Recurrence of LSLs after EMR appeared to be more frequent in patients with IBD. Given the added complexity, EMR in patients with IBD should be performed in expert centers with close endoscopic surveillance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/a-2369-7980 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sarcopenia-A Valuable Imaging Biomarker for Disease Progression in Patients With Primary Sclerosing Cholangitis (PSC)?
Liver Int
October 2025
Hannover Medical School, Department of Diagnostic and Interventional Radiology, Hannover, Germany.
Background And Aims: We aimed to ascertain the prevalence of sarcopenia in patients with primary sclerosing cholangitis (PSC) and to assess the prognostic value as a biomarker for disease outcome.
Methods: We collected data from 224 patients (148 male, 76 female; mean age 41 years) from January 2002 to December 2021, with a confirmed diagnosis of PSC who underwent magnetic resonance imaging (MRI). Muscle mass was quantified at the level of the third lumbar vertebra by measurement of psoas muscle thickness (PMT) and total psoas muscle area (PMA).
The Role of Endometriosis in Intestinal Inflammation: A Combined Mendelian Randomization and Cellular Study.
J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
This study aims to assess whether endometriosis causally increases the risk of IBD through Mendelian randomisation (MR) analysis and to elucidate potential mechanisms using in vitro experiments. A two-sample Mendelian randomisation (MR) analysis was conducted using genome-wide association study datasets for endometriosis and IBD, including ulcerative colitis and Crohn's disease. Causal inference was assessed using inverse variance weighting, MR-Egger, and weighted median methods, with MR-PRESSO used to detect horizontal pleiotropy.
View Article and Find Full Text PDFRole of ETS2 gene in inflammatory bowel disease: A narrative review.
Medicine (Baltimore)
September 2025
Department of Medicine, Ibn e Seena Hospital, Kabul, Afghanistan.
The ETS2 gene, a member of the ETS (E26 transformation-specific) family of transcription factors, plays a critical role in the regulation of immune responses, epithelial barrier integrity, and fibrosis, all of which are central to the pathogenesis of inflammatory bowel disease (IBD). This review explores the molecular characteristics of ETS2, its involvement in immune dysregulation, and its contribution to IBD-associated complications, including fibrosis and colorectal cancer. ETS2 regulates key inflammatory pathways such as NF-κB and JAK-STAT, influencing cytokine production and immune cell polarization.
View Article and Find Full Text PDFAssociation of Autoimmune Disease with Melanoma and Non-Melanoma Skin Cancers.
Clin Exp Dermatol
September 2025
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
This study examines the association between autoimmune diseases and melanoma and non-melanoma skin cancer using data from the All of Us Research Program. We conducted a cross-sectional analysis including 419,789 participants using multivariable logistic regression models adjusting for sociodemographic variables, comorbidities, and immunosuppressant use. We found significant associations between melanoma and Sjögren's syndrome, inflammatory bowel disease (IBD), vitiligo, and autoimmune thyroiditis.
View Article and Find Full Text PDFLong-Term Risk of Inflammatory Bowel Disease in Autoimmune Hepatitis: over a 20-Year Population-Based Study.
Clin Res Hepatol Gastroenterol
September 2025
Clalit Health Services, Northern Region, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Background: Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease with a recognized, but incompletely defined, association with inflammatory bowel disease (IBD). The long-term risk of developing IBD in AIH patients and its influence on hepatic outcomes remain unclear.
Aim: To determine the incidence and risk factors for IBD in a large AIH cohort over a 20-year follow-up and to assess its impact on liver-related complications.